دواعي استعمال Alfacef 750mg/30ml concentrate vial for i.v. inf
معلومات من نشرات دوائية ومراجع موثقة، مع مصدر كل معلومة. السعر الحالي: 69ج.م.
دواعي الاستعمال
- Adults (18 years and older) with infections caused by susceptible bacteria: nosocomial and community-acquired pneumonia, complicated/uncomplicated skin and skin-structure infections, chronic bacterial prostatitis, complicated/uncomplicated UTI, acute pyelonephritis, acute bacterial exacerbation of chronic bronchitis, acute bacterial sinusitis; inhalational anthrax and plague (adults and children)الفئة: Adults; selected paediatric indicationsDailyMed (US National Library of Medicine)
الآثار الجانبية
- Most common adverse reactions (>=3%) in clinical trials: nausea, headache, diarrhoea, insomnia, constipation and dizziness.نشرة دولية لنفس التركيبة · DailyMed (US National Library of Medicine)
موانع الاستعمال
- Known hypersensitivity to levofloxacin or other quinolone antibacterials.نشرة دولية لنفس التركيبة · DailyMed (US National Library of Medicine)
تحذيرات واحتياطات
- Boxed warning: disabling and potentially irreversible serious adverse reactions (tendinitis and tendon rupture, peripheral neuropathy, CNS effects) and exacerbation of myasthenia gravis; reserve for patients with no alternative treatment in acute bacterial sinusitis, acute exacerbation of chronic bronchitis and uncomplicated UTI.نشرة دولية لنفس التركيبة · DailyMed (US National Library of Medicine)
- Other warnings include hypersensitivity reactions, hepatotoxicity, Clostridioides difficile-associated diarrhoea, QT prolongation, blood glucose disturbances, photosensitivity, and aortic aneurysm/dissection risk.نشرة دولية لنفس التركيبة · DailyMed (US National Library of Medicine)
التداخلات الدوائية
- WarfarinEnhanced anticoagulant effect reported; monitor INR/prothrombin time.DailyMed (US National Library of Medicine)
- Antidiabetic agentsDisturbances of blood glucose (hypo- and hyperglycaemia) reported; monitor glucose.DailyMed (US National Library of Medicine)
- NSAIDsConcomitant use may increase the risk of CNS stimulation and convulsive seizures.DailyMed (US National Library of Medicine)
الحمل والرضاعة
- Older-format US label: levofloxacin was not teratogenic in rats or rabbits; no adequate and well-controlled studies in pregnant women; use only if benefit justifies potential fetal risk.نشرة دولية لنفس التركيبة · DailyMed (US National Library of Medicine)
- Levofloxacin is presumed to be excreted in human milk; decide whether to discontinue nursing or the drug considering its importance to the mother.نشرة دولية لنفس التركيبة · DailyMed (US National Library of Medicine)
كيف يعمل الدواء
- ليفوفلوكساسين: يثبط إنزيم الجيراز البكتيري والتوبوإيزوميراز 4.مضاد بكتيري فلوروكينولون
المصادر
- السعر: قوائم أسعار الأدوية المنشورة في مصر.
- WHO Collaborating Centre for Drug Statistics Methodology
- PubChem
- DailyMed (US National Library of Medicine)