سعر امادول 100مجم2مل 3 امبول 2024

Tramadol hydrochloride 100 mg/2 ml solution for injection, pack of 3 ampoules; centrally acting opioid analgesic.

• Treatment of moderate to severe painPopulation: Adults and adolescents >12 yearselectronic medicines compendium (emc)

• The most commonly reported adverse reactions are nausea and dizziness, both occurring in more than 10% of patients; other common effects include vomiting, constipation, dry mouth, sweating, headache, somnolence and fatigue.International label, same formulation · electronic medicines compendium (emc)

• Hypersensitivity to tramadol or any excipient; acute intoxication with alcohol, hypnotics, analgesics, opioids or psychotropic medicinal products.International label, same formulation · electronic medicines compendium (emc)
• Patients receiving MAO inhibitors or who have taken them within the last 14 days; epilepsy not adequately controlled by treatment; use in narcotic withdrawal treatment.International label, same formulation · electronic medicines compendium (emc)

• Use with particular caution in opioid-dependent patients, head injury, shock, reduced consciousness of uncertain origin, respiratory centre or function disorders and increased intracranial pressure. Concomitant benzodiazepines or other sedatives may result in sedation, respiratory depression, coma and death.International label, same formulation · electronic medicines compendium (emc)
• Convulsions (risk increased above the maximum daily dose and with seizure-threshold-lowering drugs); serotonin syndrome with serotonergic drugs; tolerance, opioid use disorder (abuse and addiction) and withdrawal on abrupt cessation; CYP2D6 ultra-rapid metabolisers are at risk of opioid toxicity; sleep-related breathing disorders and adrenal insufficiency.International label, same formulation · electronic medicines compendium (emc)

• MAO inhibitorsContraindicatedTramadol must not be combined with MAO inhibitors (life-threatening CNS, respiratory and cardiovascular interactions possible).electronic medicines compendium (emc)
• Benzodiazepines, other opioids, gabapentinoids, barbiturates, antipsychotics, H1-antihistamines, alcohol and other CNS depressantsIncreased risk of sedation, respiratory depression, coma and death; use lowest effective doses for the shortest duration.electronic medicines compendium (emc)
• SSRIs, SNRIs, tricyclic antidepressants, mirtazapine, bupropion and other seizure-threshold-lowering or serotonergic drugsMay increase the risk of convulsions and cause serotonin syndrome.electronic medicines compendium (emc)

• Tramadol crosses the placenta and there is inadequate evidence on safety in human pregnancy, so it should not be used in pregnant women; regular use may cause neonatal withdrawal; administration during labour may depress neonatal respiration.International label, same formulation · electronic medicines compendium (emc)
• Administration to nursing women is not recommended as tramadol may be secreted in breast milk and may cause respiratory depression in the infant.International label, same formulation · electronic medicines compendium (emc)

• Tramadol: Centrally acting analgesic; opioid (mu-receptor) activity plus inhibition of neuronal noradrenaline and serotonin reuptake; metabolised by CYP2D6 to an active metabolite (UK SmPC).