سعر اندوكوليست 625مجم 30 قرص 2022

Tablets containing colesevelam 625 mg (Al Andalous Pharmaceutical Industries), a bile acid sequestrant; 30 tablets per pack.

• Reduction of LDL-C in primary hyperlipidaemia (adjunct to diet and exercise)Population: Adults; boys and postmenarchal girls 10-17 years with HeFHDailyMed (U.S. National Library of Medicine)
• Glycaemic control in type 2 diabetes mellitus (adjunct to diet and exercise)Population: AdultsDailyMed (U.S. National Library of Medicine)

• Primary hyperlipidaemia trials: constipation (11%), dyspepsia (8.3%), nausea (4.2%).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Serum triglycerides >500 mg/dL; history of hypertriglyceridaemia-induced pancreatitis; history of bowel obstruction.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Can raise triglycerides and cause pancreatitis; discontinue if triglycerides exceed 500 mg/dL or pancreatitis is suspected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Gastrointestinal obstruction risk; avoid in gastroparesis, GI motility disorders or major GI surgery; tablets are large - use the suspension if swallowing is difficult.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• May decrease absorption of fat-soluble vitamins A, D, E and K; take vitamin supplements at least 4 hours before colesevelam.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Cyclosporine, phenytoin, levothyroxine, glyburide (glibenclamide), olmesartan, oral contraceptives (ethinylestradiol/norethindrone)Colesevelam decreases their exposure; administer these drugs at least 4 hours before colesevelam (monitor levels of narrow-therapeutic-index drugs).DailyMed (U.S. National Library of Medicine)
• Metformin extended-releaseColesevelam increases metformin ER exposure; monitor clinical response.DailyMed (U.S. National Library of Medicine)

• Not absorbed systemically; maternal use is not expected to result in fetal exposure. May reduce absorption of fat-soluble vitamins.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Not absorbed systemically; breastfeeding is not expected to expose the child.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Colesevelam (salt form not stated): Non-absorbed polymer that binds bile acids in the intestine; depletion of the bile acid pool increases hepatic conversion of cholesterol to bile acids and LDL-receptor numbers, lowering LDL-C. The glucose-lowering mechanism is unknown.