سعر ارثنيور 10 كبسولات 2024

Capsules combining diclofenac sodium 50 mg with thiamine mononitrate 50 mg, pyridoxine hydrochloride 50 mg and cyanocobalamin 0.25 mg; 10 capsules (Egyphar).

• Most frequent diclofenac adverse reactions (about 1-10%): abdominal pain, constipation, diarrhea, dyspepsia, flatulence, heartburn, nausea, vomiting, GI ulcers and bleeding; abnormal renal function, anemia, dizziness, edema, elevated liver enzymes, headache, increased bleeding time, pruritus, rash and tinnitus.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity (e.g. anaphylactic or serious skin reactions) to diclofenac or any component.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• History of asthma, urticaria or other allergic-type reactions after taking aspirin or other NSAIDs.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• In the setting of coronary artery bypass graft (CABG) surgery.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Boxed warning: NSAIDs increase the risk of serious cardiovascular thrombotic events (myocardial infarction, stroke), which can be fatal and may occur early in treatment.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Boxed warning: NSAIDs increase the risk of serious gastrointestinal bleeding, ulceration and perforation, which can be fatal; elderly patients and those with a history of peptic ulcer or GI bleeding are at greater risk.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Other diclofenac warnings: hepatotoxicity (monitor transaminases), hypertension, heart failure and edema, renal toxicity and hyperkalemia, anaphylactic reactions, serious skin reactions including DRESS, hematologic toxicity and fetal toxicity.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Vitamin B6: the US adult tolerable upper intake level is 100 mg/day (it does not apply to people receiving vitamin B6 under medical supervision); chronic intake of 1-6 g/day pyridoxine for 12-40 months can cause severe, progressive sensory neuropathy. At 3 capsules daily Arthineur would provide about 150 mg pyridoxine hydrochloride.General active-ingredient information · NIH Office of Dietary Supplements

• Anticoagulants (e.g. warfarin), antiplatelet agents, SSRIs/SNRIsSynergistic effect on bleeding: increased risk of serious bleeding; monitor for bleeding.DailyMed (U.S. National Library of Medicine)
• LithiumNSAIDs raise plasma lithium levels and reduce renal lithium clearance; monitor for lithium toxicity.DailyMed (U.S. National Library of Medicine)
• MethotrexateMay increase the risk of methotrexate toxicity (neutropenia, thrombocytopenia, renal dysfunction); monitor.DailyMed (U.S. National Library of Medicine)
• CyclosporineMay increase cyclosporine nephrotoxicity; monitor renal function.DailyMed (U.S. National Library of Medicine)
• Other NSAIDs or salicylatesIncreased GI toxicity with little or no gain in efficacy; concomitant use not recommended.DailyMed (U.S. National Library of Medicine)

• Diclofenac may be present in human milk; weigh the benefits of breastfeeding against the mother's need for the drug and possible effects on the infant.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Monitor for signs of GI bleeding and blood pressure; in long-term treatment check CBC, liver enzymes and renal function periodically.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Diclofenac sodium: NSAID with analgesic, anti-inflammatory and antipyretic properties; its mechanism, like other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2).
• Thiamine mononitrate (vitamin B1):
• Pyridoxine hydrochloride (vitamin B6):
• Cyanocobalamin (vitamin B12):