سعر بي تويلف 1000 مكجم 30 قرص 2026

• Chronic intake of very high doses of pyridoxine (1-6 g/day for 12-40 months) can cause severe, progressive sensory neuropathy with ataxia; symptoms usually stop when supplementation is discontinued.General active-ingredient information · NIH Office of Dietary Supplements (ODS)
• Large amounts of folic acid might mask vitamin B12 deficiency or precipitate/exacerbate its anaemia and cognitive symptoms.General active-ingredient information · NIH Office of Dietary Supplements (ODS)
• Very high biotin intakes may interfere with laboratory assays that use biotin-streptavidin technology (e.g., thyroid hormone, 25-hydroxyvitamin D), producing falsely high or low results.General active-ingredient information · NIH Office of Dietary Supplements (ODS)

• Gastric acid inhibitors (proton pump inhibitors, H2-receptor antagonists)Can interfere with absorption of vitamin B12 from food by slowing release of gastric acid.NIH Office of Dietary Supplements (ODS)
• MetforminMight reduce absorption of vitamin B12 and significantly lower serum vitamin B12 concentrations.NIH Office of Dietary Supplements (ODS)
• CycloserineIncreases urinary excretion of pyridoxine, which might exacerbate cycloserine-associated seizures and neurotoxicity; pyridoxine supplements can help prevent these effects.NIH Office of Dietary Supplements (ODS)
• Antiepileptic drugs (e.g., phenytoin, carbamazepine, valproate, phenobarbital)Antiepileptics can lower vitamin B6, folate and biotin status; high-dose pyridoxine (200 mg/day) and folate supplements might reduce serum levels of some antiepileptics - patients should consult their health care provider before taking these supplements.NIH Office of Dietary Supplements (ODS)
• MethotrexateMethotrexate is a folate antagonist; patients taking methotrexate for cancer should consult their oncologist before taking folate supplements, which could interfere with its anticancer effects.NIH Office of Dietary Supplements (ODS)

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