سعر بيسبايلير Bispyller‏ 120 كبسولة 140 مجم/125 مجم/125 مجم 2026

Bispyller 120 H.G. Caps (120 hard gelatin capsules), anti-Helicobacter pylori combination (bismuth quadruple therapy component) marketed in Egypt by Hikma Pharma.

• Most frequent (≥5%): abnormal faeces, diarrhoea, nausea and headache.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Disulfiram within the last two weeks; alcohol during and for at least 3 days after therapy; Cockayne syndrome; severe renal impairment; pregnancy; known hypersensitivity to bismuth subcitrate potassium, metronidazole or other nitroimidazoles, or tetracycline.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Fetal toxicity and tooth discoloration/enamel hypoplasia (tetracycline); maternal hepatotoxicity with high-dose IV tetracycline; severe cutaneous adverse reactions (SJS/TEN, DRESS, AGEP) with metronidazole; CNS and peripheral nervous system effects (encephalopathy, seizures, aseptic meningitis, peripheral neuropathy; intracranial hypertension with tetracycline; bismuth neurotoxicity).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• DisulfiramPsychotic reactions; do not use concurrently or within 2 weeks.DailyMed (U.S. National Library of Medicine)
• Alcohol / propylene glycolDisulfiram-like reaction; avoid during and for 3 days after therapy.DailyMed (U.S. National Library of Medicine)
• Oral contraceptivesPossible reduced efficacy; use additional contraception.DailyMed (U.S. National Library of Medicine)

• Contraindicated in pregnancy: tetracycline-class drugs in the second and third trimesters can permanently discolour teeth and may inhibit bone development; metronidazole use has been associated with some congenital anomalies.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Pump and discard breast milk during therapy and for 2 days after it ends.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Metronidazole: After passive diffusion into susceptible anaerobes it is reduced intracellularly (via electron-transport proteins such as ferredoxin) to a short-lived nitroso free radical; the reduced drug and free radicals can interact with DNA, inhibiting DNA synthesis and causing DNA degradation and bacterial death; the precise mechanism is unclear (US label).