سعر بون كير Bone care‏ 0.5مكجم 30 كبسولة 2026

Alfacalcidol 0.5 microgram oral capsules (vitamin D analogue), pack of 30.

• Common: hypercalcaemia, hyperphosphataemia, abdominal pain/discomfort, rash, pruritus; renal failure reported post-marketing.International label, equivalent formulation · electronic medicines compendium (eMC)

• Hypersensitivity to alfacalcidol or excipients; hypercalcaemia; metastatic calcification.International label, equivalent formulation · electronic medicines compendium (eMC)

• Risk of hypercalcaemia and hyperphosphataemia; monitor serum calcium and phosphate regularly, especially in children, renal impairment and high doses; caution in sarcoidosis/granulomatous disease and with digitalis.International label, equivalent formulation · electronic medicines compendium (eMC)

• Thiazide diuretics, calcium-containing preparations, other vitamin D productsIncreased risk of hypercalcaemia; monitor calcium; avoid multiple vitamin D analogues.electronic medicines compendium (eMC)
• Anticonvulsants (barbiturates, phenytoin, carbamazepine, primidone)Enzyme induction increases alfacalcidol metabolism; larger doses may be needed.electronic medicines compendium (eMC)
• Magnesium- or aluminium-containing antacids/preparationsEnhanced absorption: risk of hypermagnesaemia or raised aluminium levels.electronic medicines compendium (eMC)

• Limited human data; animal reproductive toxicity at high doses; not recommended in pregnancy or in women of child-bearing potential not using contraception.International label, equivalent formulation · electronic medicines compendium (eMC)
• Active metabolite may pass into milk; monitor breast-fed infants for hypercalcaemia.International label, equivalent formulation · electronic medicines compendium (eMC)

• Alfacalcidol: Pro-drug converted in the liver to 1,25-dihydroxyvitamin D, bypassing renal 1-alpha hydroxylation; regulates calcium and phosphate metabolism.