سعر كوزميجين ليوفاك 500مكجم 1 فيال باودر للحقن الوريدي 2026

Cosmegen lyovac 500 mcg 1 vial pd. for i.v. inj.: Dactinomycin (actinomycin D) (Orphan europe).

• As part of combination/multimodality regimens: Wilms tumor, childhood rhabdomyosarcoma, Ewing sarcoma, metastatic nonseminomatous testicular cancer; gestational trophoblastic neoplasia; regional perfusion with melphalan for locally recurrent melanoma (UK Cosmegen Lyovac SmPC — EXACT product).Population: Oncology — specialist useelectronic Medicines Compendium (eMC) / MHRA

• Nausea/vomiting early; myelosuppression, mucositis, diarrhoea, alopecia, liver toxicity/VOD, infections including fatal sepsis (UK Cosmegen).International label, same product · electronic Medicines Compendium (eMC) / MHRA

• Hypersensitivity to dactinomycin or excipients; use in patients with varicella or herpes zoster (UK Cosmegen).International label, same product · electronic Medicines Compendium (eMC) / MHRA

• HIGHLY TOXIC / corrosive; IV use only; extravasation causes severe soft-tissue damage; myelosuppression, VOD (esp. children <48 months), radiation recall; monitor renal/hepatic/marrow (UK Cosmegen).International label, same product · electronic Medicines Compendium (eMC) / MHRA

• Teratogenic in animals; should not normally be given to pregnant women. Effective contraception: women ≥7 months after last dose; men ≥4 months (UK Cosmegen).International label, same product · electronic Medicines Compendium (eMC) / MHRA
• Should not be administered to mothers who are breast-feeding (UK Cosmegen).International label, same product · electronic Medicines Compendium (eMC) / MHRA

• Dactinomycin: Forms stable complex with DNA and interferes with DNA-dependent RNA synthesis.