سعر كومادين 5 مجم 28 قرص مستورد 2022

Coumadin 5 mg 28 tablets (illegal import): Warfarin (Zentiva).

• Prophylaxis and treatment of venous thrombosis and its extension, pulmonary embolism; prophylaxis and treatment of thromboembolic complications associated with atrial fibrillation and/or cardiac valve replacement; reduction in risk of death, recurrent MI, and thromboembolic events after MI.Population: Adults requiring anticoagulationDailyMed (U.S. National Library of Medicine)

• Pregnancy (except selected women with mechanical heart valves); hemorrhagic tendencies or blood dyscrasias; recent or contemplated CNS/eye surgery or traumatic surgery resulting in large open surfaces; bleeding tendencies associated with active ulceration or overt bleeding; unsupervised patients with potential high non-compliance; spinal puncture and other diagnostic/therapeutic procedures with potential for uncontrollable bleeding; major regional or lumbar block anesthesia; malignant hypertension; known hypersensitivity.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• BOXED WARNING: major or fatal bleeding. Tissue necrosis/gangrene can occur. Calciphylaxis reported. Regular INR monitoring mandatory. Many drug-food interactions (vitamin K).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• CYP2C9 modulators / hemostasis-affecting drugs (NSAIDs, antiplatelets, some antibiotics)MajorMajor INR changes possible — monitor closely.DailyMed (U.S. National Library of Medicine)
• Vitamin K-rich foods / sudden dietary changesModerateCan alter INR response.DailyMed (U.S. National Library of Medicine)

• Warfarin can cause fetal harm; contraindicated in pregnancy except selected mechanical valve cases where benefits may outweigh risks (US label).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Warfarin: Inhibits vitamin K epoxide reductase (VKORC1), depleting reduced vitamin K needed for clotting factors II, VII, IX, X.