سعر سيكلوجست 400مجم 15 اقماع لبوس مهبلي 2024

Cyclogest 400mg 15 rectal or vag. pessaries: Progesterone (Actavis > multipharma).

• UK Cyclogest 400 mg pessaries: treatment of premenstrual syndrome including premenstrual tension and depression; puerperal depression; luteal phase support as part of ART (MHRA/eMC SmPC).Population: Adult women (labeled indications)electronic Medicines Compendium (eMC) / MHRA

• Common: somnolence, abdominal pain/discomfort, breast pain; with ART also abdominal distension, constipation, hot flush, fatigue; rectal use may cause diarrhoea/flatulence; local leakage/soreness (UK Cyclogest SmPC).International label, same product · electronic Medicines Compendium (eMC) / MHRA

• Hypersensitivity; undiagnosed vaginal bleeding; known/suspected progesterone-sensitive malignancy; porphyria; severe hepatic dysfunction; known missed abortion or ectopic pregnancy; active or severe history of arterial/venous thromboembolism or thrombophlebitis (UK Cyclogest SmPC).International label, same product · electronic Medicines Compendium (eMC) / MHRA

• Not indicated in threatened miscarriage; discontinue if thromboembolic events suspected; caution in depression history, fluid-retention-sensitive conditions, diabetes, hepatic dysfunction; abrupt discontinuation may increase anxiety/moodiness (UK SmPC).International label, same product · electronic Medicines Compendium (eMC) / MHRA

• CYP3A4 inducers (rifampicin, carbamazepine, phenytoin)ModerateMay increase progesterone elimination and decrease bioavailability (UK Cyclogest SmPC).electronic Medicines Compendium (eMC) / MHRA
• Other vaginal productsEffect of concomitant vaginal products on Cyclogest exposure not assessed — not recommended (UK SmPC).electronic Medicines Compendium (eMC) / MHRA

• Should not be used during pregnancy except as indicated in first trimester for ART luteal support; limited/inconclusive congenital anomaly data (UK Cyclogest SmPC).International label, same product · electronic Medicines Compendium (eMC) / MHRA
• Progesterone is excreted in human milk; Cyclogest should not be used during breast-feeding (UK SmPC).International label, same product · electronic Medicines Compendium (eMC) / MHRA

• Progesterone: Transforms proliferative endometrium into secretory endometrium in the presence of adequate estrogen; necessary for endometrial receptivity and pregnancy maintenance.