سعر ديوروجيسك 25 ميكروجرام/ساعة 5 لصقات جلدية 2024

Durogesic 25mcg/hr 5 transdermal patch — Fentanyl (Janssen Cilag).

• Management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate — in opioid-tolerant patients only (US fentanyl transdermal label). Directory notes strong analgesic under medical supervision.Population: AdultsDailyMed (NLM)

• Common: nausea, vomiting, constipation, somnolence, dizziness, headache, insomnia, sweating, pruritus, application-site reactions; serious: respiratory depression, hypotension, adrenal insufficiency, serotonin syndrome with serotonergic drugs, anaphylaxis (US label).International label, same formulation · DailyMed (NLM)

• Opioid-nontolerant patients; management of acute/postoperative/mild/intermittent pain; significant respiratory depression; acute/severe asthma in unmonitored settings; known/suspected GI obstruction including paralytic ileus; hypersensitivity to fentanyl (US fentanyl patch boxed labeling).International label, same formulation · DailyMed (NLM)

• BOXED WARNING: addiction, abuse, misuse; life-threatening respiratory depression; accidental exposure can be fatal especially in children; CYP3A4 inhibitors increase exposure; neonatal opioid withdrawal with prolonged use in pregnancy; risk with benzodiazepines/CNS depressants; risk of application-site heat increasing release. Dispose of used patches safely (US fentanyl transdermal label).International label, same formulation · DailyMed (NLM)

• CYP3A4 inhibitors/inducers; CNS depressants; MAOIs; serotonergic drugsMajorCYP3A4 inhibitors increase fentanyl levels (respiratory depression risk); CYP3A4 inducers decrease levels; CNS depressants/alcohol/benzodiazepines additive depression; MAOIs within 14 days contraindicated/ caution; serotonergic drugs — serotonin syndrome risk (US label). Management: Avoid or monitor closely; consider dose adjustments per label.DailyMed (NLM)

• Prolonged opioid use in pregnancy can result in neonatal opioid withdrawal syndrome. Crosses placenta. Use only if benefits outweigh risks; counsel (US fentanyl patch PLLR).International label, same formulation · DailyMed (NLM)
• Fentanyl is present in breast milk; infants may experience sedation/respiratory depression — advise against breastfeeding or discontinue drug per risk/benefit (US label).International label, same formulation · DailyMed (NLM)

• Fentanyl: Potent synthetic agonist of mu-opioid receptors in the brain and spinal cord, reducing pain perception; also causes respiratory depression and sedation.