سعر اندوكسان 1 جم فيال 2024

Cyclophosphamide 1 g powder for solution for injection (vial) (Baxter Oncology Germany Endoxan; Egyptian distributor listed as Multipharma).

• Malignant diseases in adults and children: malignant lymphomas (Hodgkin disease, lymphocytic, mixed-cell, histiocytic and Burkitt lymphoma), multiple myeloma, leukemias, mycosis fungoides, neuroblastoma, ovarian adenocarcinoma, retinoblastoma, breast carcinoma; biopsy-proven minimal change nephrotic syndrome in pediatric patients unresponsive to or intolerant of corticosteroids.Population: Adults and pediatric patientsDailyMed (U.S. NLM)

• History of severe hypersensitivity to cyclophosphamide, its metabolites or product components (anaphylaxis incl. death reported; cross-sensitivity with other alkylating agents possible); urinary outflow obstruction.International label, same formulation · DailyMed (U.S. NLM)

• Myelosuppression, immunosuppression, bone marrow failure and serious/fatal infections (close hematologic monitoring); urinary tract and renal toxicity incl. hemorrhagic cystitis (ensure hydration, exclude obstruction); cardiotoxicity; pulmonary toxicity; secondary malignancies; veno-occlusive liver disease; infertility; embryo-fetal toxicity.International label, same formulation · DailyMed (U.S. NLM)

• Protease inhibitorsMay increase cytotoxic metabolite concentrations and toxicities (infections, neutropenia, mucositis); monitor.DailyMed (U.S. NLM)
• Radiation therapy or drugs with similar toxicitiesMay potentiate cyclophosphamide toxicities; monitor.DailyMed (U.S. NLM)

• Can cause fetal harm: exposure may cause fetal malformations, miscarriage, fetal growth retardation and toxic effects in the newborn; advise of risk.International label, same formulation · DailyMed (U.S. NLM)
• Present in breast milk; neutropenia, thrombocytopenia, low hemoglobin and diarrhea reported in breastfed infants; do not breastfeed during treatment and for 1 week after the last dose.International label, same formulation · DailyMed (U.S. NLM)

• Cyclophosphamide: Prodrug activated by hepatic metabolism to alkylating metabolites that cross-link DNA, interfering with cell division (alkylating drug per US label).