سعر فليكسونيز مائي بخاخ للانف 50مكجم/جرعة سبراي 2025

Flixonase aqueous nasal spray, fluticasone propionate 50 micrograms per metered dose, 120 doses, by GlaxoSmithKline; nasal corticosteroid for allergic rhinitis.

• Prophylaxis and treatment of seasonal allergic rhinitis, including hay fever, and of perennial rhinitis.Population: Adults and children 4 years and overelectronic medicines compendium (eMC)

• Very common: epistaxis. Common: headache, unpleasant taste or smell, and dryness or irritation of the nose and throat.International label, same formulation · electronic medicines compendium (eMC)
• Very rare: hypersensitivity reactions (including anaphylaxis, angioedema and bronchospasm), glaucoma, raised intraocular pressure, cataract and nasal septal perforation. Frequency not known: blurred vision and nasal ulcers.International label, same formulation · electronic medicines compendium (eMC)

• Hypersensitivity to fluticasone propionate or to any of the excipients.International label, same formulation · electronic medicines compendium (eMC)

• Local nasal infections should be treated appropriately; care is needed when transferring patients from systemic corticosteroids if adrenal function may be impaired.International label, same formulation · electronic medicines compendium (eMC)
• Systemic corticosteroid effects may occur, particularly at high doses for prolonged periods; growth retardation has been reported in children on nasal corticosteroids, so monitor height regularly and use the lowest effective dose. Doses above those recommended may cause clinically significant adrenal suppression.International label, same formulation · electronic medicines compendium (eMC)
• Visual disturbance (for example blurred vision or central serous chorioretinopathy) may occur; refer to an ophthalmologist.International label, same formulation · electronic medicines compendium (eMC)

• Ritonavir and cobicistat-containing productsRitonavir can increase fluticasone propionate plasma levels several hundred-fold, causing systemic corticosteroid effects including Cushing's syndrome and adrenal suppression; avoid unless the benefit outweighs the risk.electronic medicines compendium (eMC)
• Ketoconazole, itraconazole and other potent CYP3A4 inhibitorsKetoconazole increased exposure to inhaled fluticasone propionate by about 150%; use potent CYP3A4 inhibitors with caution.electronic medicines compendium (eMC)

• There is inadequate evidence of safety in human pregnancy; use only if the benefit to the mother outweighs the possible hazard to the fetus. Systemic exposure after intranasal use is minimal.International label, same formulation · electronic medicines compendium (eMC)
• Excretion in human milk has not been investigated; plasma levels after intranasal use are low, so detectable milk levels are unlikely; weigh the benefit against the possible risk.International label, same formulation · electronic medicines compendium (eMC)

• Fluticasone propionate: Glucocorticoid with potent anti-inflammatory activity in the lungs or nasal mucosa at recommended doses, with low systemic exposure (UK Flixotide/Flixonase SmPCs, section 5.1).