سعر جاستروموتيل 10مجم 20 قرص 2024

Domperidone 10 mg film-coated tablets, 20 per pack, by EIPICO.

• Relief of the symptoms of nausea and vomiting.Population: Adults and adolescents 12 years and older weighing 35 kg or moremedicines.ie (HPRA-approved SmPC), Ireland

• Common: dry mouth. Other listed reactions include somnolence, headache, dizziness, anxiety, diarrhoea, rash, pruritus, urticaria, galactorrhoea, breast pain/tenderness, and (frequency not known) anaphylactic reactions, convulsion, extrapyramidal disorder, oculogyric crisis, ventricular arrhythmias, QTc prolongation, torsade de pointes, sudden cardiac death, gynaecomastia and urinary retention.International label, same formulation · medicines.ie (HPRA-approved SmPC), Ireland

• Hypersensitivity to domperidone or excipients; prolactin-releasing pituitary tumour (prolactinoma); when stimulation of gastric motility could be harmful (GI haemorrhage, mechanical obstruction or perforation); moderate or severe hepatic impairment; known prolongation of cardiac conduction intervals (particularly QTc), significant electrolyte disturbances or underlying cardiac disease such as congestive heart failure; co-administration with QT-prolonging drugs (except apomorphine) or potent CYP3A4 inhibitors; confirmed or suspected pheochromocytoma.International label, same formulation · medicines.ie (HPRA-approved SmPC), Ireland

• Domperidone is associated with an increased risk of serious ventricular arrhythmias and sudden cardiac death, higher in patients older than 60 years and at daily doses above 30 mg; use the lowest effective dose. Stop treatment if signs of arrhythmia occur.International label, same formulation · medicines.ie (HPRA-approved SmPC), Ireland

• Potent CYP3A4 inhibitors (e.g. ketoconazole, itraconazole, erythromycin, clarithromycin, protease inhibitors) and QT-prolonging drugsContraindicatedCo-administration is contraindicated: CYP3A4 inhibitors raise domperidone levels (ketoconazole and erythromycin about three-fold) and add QT-prolonging effects.medicines.ie (HPRA-approved SmPC), Ireland
• Antacids and antisecretory agentsShould not be taken simultaneously with oral domperidone as they lower its oral bioavailability.medicines.ie (HPRA-approved SmPC), Ireland

• Limited post-marketing data in pregnancy; animal studies showed reproductive toxicity at maternally toxic doses. Use only when justified by the anticipated therapeutic benefit.International label, same formulation · medicines.ie (HPRA-approved SmPC), Ireland
• Excreted in human milk; breastfed infants receive less than 0.1% of the maternal weight-adjusted dose. Risk of cardiac effects in the infant cannot be excluded; decide whether to stop breastfeeding or therapy.International label, same formulation · medicines.ie (HPRA-approved SmPC), Ireland

• Domperidone: Peripherally acting dopamine antagonist with anti-emetic properties (gastrokinetic effects and antagonism at the chemoreceptor trigger zone); does not readily cross the blood-brain barrier; raises prolactin (SmPC).