سعر كاتيفاروكس 50 مجم فيال 2022

Egyptian brivaracetam 50 mg injection vial (Multi-Apex) for intravenous use in partial-onset seizures.

• Treatment of partial-onset seizuresPopulation: Patients 1 month of age and olderDailyMed (U.S. National Library of Medicine)

• Most common in adults (at least 5% and at least 2% more than placebo): somnolence/sedation, dizziness, fatigue, nausea/vomiting; similar in children.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to brivaracetam or any inactive ingredient (bronchospasm and angioedema have occurred).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Antiepileptic drugs increase the risk of suicidal thoughts or behaviour; monitor for depression and mood changes.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Somnolence and fatigue (avoid driving or operating machinery until effects are known); psychiatric reactions (psychotic symptoms, irritability, depression, aggression, anxiety); hypersensitivity (bronchospasm, angioedema); serious dermatologic reactions; withdraw gradually to avoid increased seizures and status epilepticus.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• RifampinDecreases brivaracetam concentrations (CYP2C19 induction); increase brivaracetam dose by up to 100%.DailyMed (U.S. National Library of Medicine)
• CarbamazepineIncreases exposure to carbamazepine-epoxide; consider carbamazepine dose reduction if tolerability issues arise.DailyMed (U.S. National Library of Medicine)
• PhenytoinPhenytoin concentrations can increase; monitor levels.DailyMed (U.S. National Library of Medicine)

• Available pregnancy data (NAAED registry, case reports) are insufficient to identify a risk of major birth defects or miscarriage; animal studies showed developmental toxicity at exposures above clinical levels. Enrolment in the NAAED Pregnancy Registry is encouraged.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Brivaracetam is present in human milk; information on effects on the breastfed infant or milk production is insufficient.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Brivaracetam: Binds selectively and with high affinity to synaptic vesicle protein 2A (SV2A) in the brain.