سعر كيتريل 3 مجم / 3 مل 5 امبولات 2022

Granisetron 3 mg/3 ml (1 mg/ml) ampoules for intravenous injection or infusion (5 per pack), a 5-HT3 antagonist antiemetic.

• Adults: prevention and treatment of acute nausea and vomiting with chemotherapy and radiotherapy, prevention of delayed CINV/RINV, and post-operative nausea and vomiting.Population: Adultselectronic medicines compendium (emc)
• Children 2 years and above: prevention and treatment of acute chemotherapy-induced nausea and vomiting.Population: Children aged 2 years and aboveelectronic medicines compendium (emc)

• Very common: headache, constipation. Common: insomnia, diarrhoea, raised transaminases. Uncommon: hypersensitivity, extrapyramidal reactions, serotonin syndrome, QT prolongation, rash.International label, same formulation · electronic medicines compendium (emc)

• Hypersensitivity to granisetron or any excipient.International label, same formulation · electronic medicines compendium (emc)

• May reduce lower bowel motility; monitor patients with signs of sub-acute intestinal obstruction.International label, same formulation · electronic medicines compendium (emc)
• ECG changes including QT prolongation reported; caution with cardiac co-morbidity, cardiotoxic chemotherapy or electrolyte abnormalities.International label, same formulation · electronic medicines compendium (emc)
• Serotonin syndrome reported with 5-HT3 antagonists, mostly with other serotonergic drugs (SSRIs, SNRIs).International label, same formulation · electronic medicines compendium (emc)

• Phenobarbital (hepatic enzyme induction)Increases total plasma clearance of granisetron by about 25%.electronic medicines compendium (emc)
• QT-prolonging or arrhythmogenic drugsMay lead to clinical consequences of QT prolongation.electronic medicines compendium (emc)
• Serotonergic drugs (SSRIs, SNRIs)Serotonin syndrome reported with concomitant use.electronic medicines compendium (emc)

• Limited human data; animal studies show no harmful reproductive effects; as a precaution, preferably avoid in pregnancy.International label, same formulation · electronic medicines compendium (emc)
• Unknown whether excreted in milk; breastfeeding should not be advised during treatment.International label, same formulation · electronic medicines compendium (emc)

• Granisetron (as hydrochloride): Highly selective 5-HT3 receptor antagonist acting on vagal terminals and the chemoreceptor trigger zone (UK SmPC 5.1).