سعر ميمانتينا هيدروكلوريد 10مجم/مل شراب 50مل 2022

Memantine hydrochloride 10 mg/ml oral solution (listed as syrup), 50 ml bottle with dropper, by Chanelle Pharmaceuticals for Diligence Pharma; used for Alzheimer's-type dementia.

• Treatment of adult patients with moderate to severe Alzheimer's disease.Population: Adultselectronic medicines compendium (emc), United Kingdom

• Common adverse reactions include dizziness, headache, constipation, somnolence, hypertension, dyspnoea, balance disorders, drug hypersensitivity and elevated liver function tests.International label, same formulation · electronic medicines compendium (emc), United Kingdom

• Hypersensitivity to the active substance or any excipient.International label, same formulation · electronic medicines compendium (emc), United Kingdom

• Use with caution in epilepsy or a history of convulsions; avoid concomitant use with other NMDA antagonists such as amantadine, ketamine or dextromethorphan; factors that raise urine pH may require close monitoring.International label, same formulation · electronic medicines compendium (emc), United Kingdom
• Contains sorbitol (UK product): patients with hereditary fructose intolerance should not take it.International label, same formulation · electronic medicines compendium (emc), United Kingdom

• Other NMDA antagonists (amantadine, ketamine, dextromethorphan)Avoid combined use because of the risk of pharmacotoxic psychosis.electronic medicines compendium (emc), United Kingdom
• Warfarin and other oral anticoagulantsIsolated reports of increased INR; close monitoring of prothrombin time/INR is advisable.electronic medicines compendium (emc), United Kingdom

• Should not be used during pregnancy unless clearly necessary (no clinical data on exposed pregnancies; animal studies indicate potential for reduced intrauterine growth).International label, same formulation · electronic medicines compendium (emc), United Kingdom
• Women taking memantine should not breastfeed (excretion in milk is likely given its lipophilicity).International label, same formulation · electronic medicines compendium (emc), United Kingdom

• Memantine: Postulated to act as a low-to-moderate affinity uncompetitive (open-channel) NMDA receptor antagonist, reducing effects of persistent glutamatergic activation; no evidence that it prevents or slows neurodegeneration (US label).