سعر ميجرانيل 30 قرص 2023

Antimigraine combination tablets by El Nile (Egypt) containing ergotamine, caffeine, meprobamate, metamizole (analgin) and phenobarbital; pack of 30. Ingredient strengths were not stated by the sources opened.

• Ergotamine (US Cafergot label, as summarised in the shared cache): pregnancy, peripheral vascular disease, coronary heart disease, hypertension, hepatic or renal impairment, sepsis, and co-use with potent CYP3A4 inhibitors.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Metamizole: patients at increased risk of agranulocytosis or with bone-marrow/haematopoietic disorders (EMA referral, as summarised in the shared cache).General active-ingredient information · European Medicines Agency (EMA)

• Ergotamine (US Cafergot label, as summarised in the shared cache): boxed warning for serious peripheral ischaemia when combined with potent CYP3A4 inhibitors (e.g. protease inhibitors, macrolides); fibrotic complications, ergotism and abuse/dependence reported.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Metamizole (EMA referral, as summarised in the shared cache): agranulocytosis can occur at any time, independent of dose; stop and seek immediate medical attention for fever, chills, sore throat or mucosal sores (urgent blood count).General active-ingredient information · European Medicines Agency (EMA)
• Meprobamate: in 2012 the EMA recommended suspending all EU marketing authorisations for oral meprobamate medicines because risks (serious nervous-system effects including potentially fatal coma, a narrow margin between therapeutic and harmful doses, and dependence with serious withdrawal effects) outweigh benefits.General active-ingredient information · European Medicines Agency (EMA)

• Potent CYP3A4 inhibitors (protease inhibitors, macrolide antibiotics)Contraindicated with ergotamine: risk of ergotism and serious peripheral/cerebral ischaemia.DailyMed (U.S. National Library of Medicine)

• Ergotamine is contraindicated in pregnancy (oxytocic effect) per the US Cafergot label.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

English text not available for this section.