سعر ميكسمازيل 28/10 مجم 28 كبسولة ممتدة المفعول 2024

Mixmazil 28/10 mg extended-release capsules, pack of 28 (Hikma): memantine hydrochloride 28 mg + donepezil hydrochloride 10 mg ER.

• Treatment of moderate to severe dementia of the Alzheimer type in patients already stabilized on donepezil (NAMZARIC indication). Directory Arabic text similarly describes Alzheimer-related cognitive support.Population: Adults with Alzheimer dementia (per US label)DailyMed

• Known hypersensitivity to memantine hydrochloride, donepezil hydrochloride, piperidine derivatives, or any excipients (NAMZARIC).International label, same formulation · DailyMed

• May exaggerate succinylcholine-type muscle relaxation during anesthesia; vagotonic effects (bradycardia/heart block) possible; use caution with sick sinus syndrome or other supraventricular cardiac conduction conditions; monitor for GI bleeding risk as with other cholinomimetics; nausea/vomiting/diarrhea possible (NAMZARIC).International label, same formulation · DailyMed

• No adequate data on NAMZARIC use in pregnant women; use only if potential benefit justifies potential risk (see US labeling).International label, same formulation · DailyMed

• Memantine: Postulated to act as a low-to-moderate affinity uncompetitive (open-channel) NMDA receptor antagonist, reducing effects of persistent glutamatergic activation; no evidence that it prevents or slows neurodegeneration (US label).
• Donepezil: Postulated to enhance cholinergic function by increasing acetylcholine concentrations through reversible inhibition of its hydrolysis by acetylcholinesterase; there is no evidence that it alters the course of the underlying dementing process (US label).