سعر نافيلبين 50مجم/5مل فيال وريد 2022

Navelbine 50 mg IV vial (Pierre Fabre France / Egyptian Pharmaceutical Trading Company): vinorelbine concentrate for IV infusion, 50 mg in 5 ml (10 mg/ml). Same brand as UK Navelbine IV concentrate.

• Stage 3 or 4 NSCLC first-line as single agent or in combination; advanced breast cancer stage 3/4 after anthracycline failure (UK Navelbine SmPC).Population: AdultsMedicines.org.uk (eMC) / MHRA
• Directory Arabic text: antineoplastic — for cancer treatment (Egyptian leaflet not opened).

• Myelosuppression is dose-limiting; other important risks include constipation/bowel obstruction, neuropathy, hepatic laboratory abnormalities, infusion-site reactions, nausea, alopecia (see full labels).International label, same product · Medicines.org.uk (eMC) / MHRA, DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to vinorelbine or other vinca alkaloids or excipients; neutrophil count <1500/mm³ or severe current/recent infection; platelet count <100000/mm³; yellow fever vaccine combination; lactation.International label, same product · Medicines.org.uk (eMC) / MHRA

• US boxed warning: severe myelosuppression with infection, septic shock, hospitalization and death — decrease dose or withhold per modifications. Also hepatic toxicity, severe constipation/ileus, extravasation injury, neuropathy, pulmonary toxicity.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• CYP3A4 inhibitorsModerateMay cause earlier onset and/or increased severity of adverse reactions (US label).DailyMed (U.S. National Library of Medicine)
• Yellow fever vaccineMajorContraindicated in combination (UK SmPC).Medicines.org.uk (eMC) / MHRA

• Vinorelbine can cause fetal harm based on mechanism and animal data; advise pregnant women of potential risk (US/UK labels).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• UK contraindication: lactation. US: advise not to breastfeed during treatment and for 9 days after the final dose.International label, same product · Medicines.org.uk (eMC) / MHRA, DailyMed (U.S. National Library of Medicine)

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