سعر نيرهابيزيل 5مجم 14 فيلم 2024

Donepezil 5 mg orodispersible film (Nerhadou International Co.); acetylcholinesterase inhibitor listed for Alzheimer's-type dementia.

• Treatment of dementia of the Alzheimer's type; efficacy shown in mild, moderate and severe Alzheimer's diseasePopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions (≥5% and twice placebo): nausea, diarrhea, insomnia, vomiting, muscle cramps, fatigue and anorexia.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to donepezil hydrochloride or to piperidine derivatives.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Anesthesia: likely to exaggerate succinylcholine-type muscle relaxation during anesthesia.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Cardiovascular: vagotonic effects on heart rate (bradycardia, heart block); syncopal episodes have been reported.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Gastrointestinal: nausea, vomiting and diarrhea (more frequent with 10 mg and 23 mg); monitor for active or occult GI bleeding, especially in patients with ulcer history or on NSAIDs.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Anticholinergic medicationsDonepezil has the potential to interfere with the activity of anticholinergic medications.DailyMed (U.S. National Library of Medicine)
• Succinylcholine, similar neuromuscular blockers and cholinergic agonists (e.g., bethanechol)A synergistic effect may be expected with concomitant succinylcholine, similar neuromuscular blocking agents or cholinergic agonists such as bethanechol.DailyMed (U.S. National Library of Medicine)

• There are no adequate data on developmental risks with donepezil in pregnant women; in rats, administration during late pregnancy and lactation increased stillbirths and reduced offspring survival at doses above those without effect.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• There are no data on the presence of donepezil in human milk, effects on the breastfed infant or on milk production; weigh benefits of breastfeeding against the mother's need for the drug.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Donepezil: Postulated to enhance cholinergic function by increasing acetylcholine concentrations through reversible inhibition of its hydrolysis by acetylcholinesterase; there is no evidence that it alters the course of the underlying dementing process (US label).