سعر نوفراكت 70مجم شرب 75 مل 2025

Nofract 70 mg oral solution (Jasper/EGPI, Egypt): alendronate 70 mg in a 75 ml single-dose oral solution, a once-weekly bisphosphonate for osteoporosis.

• Treatment of osteoporosis in postmenopausal women (increases bone mass and reduces vertebral and hip fractures).Population: Postmenopausal womenDailyMed (U.S. National Library of Medicine)
• Treatment to increase bone mass in men with osteoporosis.Population: Adult menDailyMed (U.S. National Library of Medicine)

• Most common (3% or more): abdominal pain, acid regurgitation, constipation, diarrhoea, dyspepsia, musculoskeletal pain, nausea.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Oesophageal abnormalities that delay emptying (stricture, achalasia); inability to stand or sit upright for at least 30 minutes; patients at increased risk of aspiration (oral solution); hypocalcaemia; hypersensitivity to any component.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Upper GI mucosal irritation, oesophagitis, ulcers and erosions; discontinue and seek care if dysphagia, odynophagia, retrosternal pain or new/worsening heartburn occur.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Correct hypocalcaemia and other mineral metabolism disorders (e.g. vitamin D deficiency) before starting; ensure adequate calcium and vitamin D.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Severe bone, joint or muscle pain may occur; osteonecrosis of the jaw; atypical femoral fractures (evaluate new thigh or groin pain).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Calcium supplements, antacids, multivalent cationsInterfere with absorption; wait at least 30 minutes after alendronate before taking any other oral medication.DailyMed (U.S. National Library of Medicine)
• AspirinIncreased incidence of upper GI adverse events with alendronate doses above 10 mg daily plus aspirin-containing products.DailyMed (U.S. National Library of Medicine)
• NSAIDsMay be co-administered, but caution because NSAIDs are associated with GI irritation.DailyMed (U.S. National Library of Medicine)

• Available data are insufficient to inform a drug-associated risk; discontinue alendronate when pregnancy is recognised. Bisphosphonates are incorporated into bone and released over years; animal studies showed adverse developmental and maternal hypocalcaemia-related effects.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Not known whether alendronate is present in human milk or affects the breastfed infant or milk production; weigh breastfeeding benefits against the mother's clinical need.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Alendronate (alendronic acid): Binds to bone hydroxyapatite and inhibits osteoclast-mediated bone resorption.