دواعي استعمال بوفول 10مجم/مل امبول

Propofol 10 mg/ml intravenous general anaesthetic (Pofol) listed in Egypt by Dong Kook Pharm (Korea) / EIMC.

• Induction of general anaesthesia (patients >= 3 years)DailyMed (US NLM)
• Maintenance of general anaesthesia (patients >= 2 months)DailyMed (US NLM)
• Initiation and maintenance of monitored anaesthesia care (MAC) sedation in adults; sedation of intubated, mechanically ventilated adults in ICUDailyMed (US NLM)

• Clinically important: hypersensitivity reactions, hypotension and/or bradycardia, propofol infusion syndrome; injection-site pain is frequent.نشرة دولية لتركيبة مكافئة · DailyMed (US NLM)

• Known hypersensitivity to propofol or any component; history of anaphylaxis to eggs, egg products, soybeans or soy products.نشرة دولية لتركيبة مكافئة · DailyMed (US NLM)

• Fatal and life-threatening anaphylactic and anaphylactoid reactions have been reported.نشرة دولية لتركيبة مكافئة · DailyMed (US NLM)
• Risk of microbial contamination: strict aseptic technique must be maintained; the emulsion can support microbial growth.نشرة دولية لتركيبة مكافئة · DailyMed (US NLM)
• Bradycardia, asystole and rarely cardiac arrest; hypotension, especially in elderly, debilitated or ASA-PS III/IV patients.نشرة دولية لتركيبة مكافئة · DailyMed (US NLM)
• Propofol infusion syndrome (metabolic acidosis, hyperkalaemia, lipaemia, rhabdomyolysis, renal failure) reported with ICU sedation infusions, sometimes fatal.نشرة دولية لتركيبة مكافئة · DailyMed (US NLM)
• Caution in disorders of lipid metabolism; serum triglycerides may rise with prolonged infusion.نشرة دولية لتركيبة مكافئة · DailyMed (US NLM)
• Repeated or prolonged use of anaesthetic/sedation drugs in young children or in pregnancy (third trimester) may affect brain development (animal data).نشرة دولية لتركيبة مكافئة · DailyMed (US NLM)
• Seizure risk during recovery in epileptic patients; transient local pain on injection; rare pancreatitis and pulmonary oedema.نشرة دولية لتركيبة مكافئة · DailyMed (US NLM)

• Data from randomised trials, cohort studies and case series over several decades have not identified a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes; most exposures were at caesarean delivery.نشرة دولية لتركيبة مكافئة · DailyMed (US NLM)
• Propofol is present in human milk at variable concentrations; available data have not shown adverse reactions in breastfed infants.نشرة دولية لتركيبة مكافئة · DailyMed (US NLM)

• Continuously monitor for early signs of hypotension, bradycardia and apnoea; monitor triglycerides with prolonged infusion.نشرة دولية لتركيبة مكافئة · DailyMed (US NLM)

• بروبوفول: تعديل إيجابي لمستقبلات GABA-A؛ منوّم وريدي قصير المفعول لتحريض/إبقاء التخدير والتهدئة.مخدر عام وريدي / منوّم