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دواعي استعمال بونفوري 20مجم 28 قرص

معلومات من نشرات دوائية ومراجع موثقة، مع مصدر كل معلومة. السعر الحالي: 22,000ج.م.

دواعي الاستعمال
  • Relapsing forms of multiple sclerosis (clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease) in adults.الفئة: AdultsDailyMed (U.S. National Library of Medicine)
الآثار الجانبية
  • Most common adverse reactions (at least 10%): upper respiratory tract infection, hepatic transaminase elevation and hypertension.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
موانع الاستعمال
  • In the last 6 months: myocardial infarction, unstable angina, stroke, TIA, decompensated heart failure requiring hospitalization, or Class III/IV heart failure.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Mobitz type II second-degree or third-degree AV block, sick sinus syndrome or sino-atrial block, unless a functioning pacemaker is present.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
تحذيرات واحتياطات
  • Infections: may increase infection risk; obtain a CBC before starting, do not start during active infection, and monitor for infection during treatment and for 1-2 weeks after stopping.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Bradyarrhythmia and AV conduction delays at initiation: titration is required; first-dose 4-hour monitoring for patients with sinus bradycardia, first- or second-degree (Mobitz I) AV block, or prior MI/heart failure.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Other warnings: decline in pulmonary function, liver injury, increased blood pressure, cutaneous malignancies (skin examination recommended), and fetal risk (effective contraception during treatment and for about 1 week after stopping).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
الحمل والرضاعة
  • No adequate studies in pregnant women; in rats and rabbits ponesimod caused embryolethality and fetal malformations at clinically relevant exposures. Women of childbearing potential should use effective contraception.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • No data on presence in human milk; consider benefits of breastfeeding against the mother's need for ponesimod and potential infant effects.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
المتابعة أثناء العلاج
  • Baseline ECG, CBC with lymphocyte count and liver tests; monitor blood pressure during treatment; periodic skin examination; spirometry if clinically indicated.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
سعر بونفوري 20مجم 28 قرصالمثائل والبدائل

المصادر