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دواعي استعمال بوساكونكس 300مجم فيال للحقن الوريدي ببطء 16.7 مل

معلومات من نشرات دوائية ومراجع موثقة، مع مصدر كل معلومة. السعر الحالي: 530ج.م.

دواعي الاستعمال
  • Treatment of invasive aspergillosis in adults and pediatric patients 2 years and older weighing at least 10 kg.الفئة: Adults and children >=2 years (>=10 kg)DailyMed (U.S. National Library of Medicine)
  • Prophylaxis of invasive Aspergillus and Candida infections in severely immunocompromised patients at high risk (e.g. HSCT recipients with GVHD, haematologic malignancies with prolonged neutropenia).الفئة: Adults and children >=2 years (>=10 kg)DailyMed (U.S. National Library of Medicine)
الآثار الجانبية
  • Common adverse reactions in adults include diarrhoea, nausea, fever, vomiting, headache, coughing and hypokalaemia; in children (>20%) pyrexia, febrile neutropenia, vomiting, mucosal inflammation, pruritus, hypertension, hypokalaemia and stomatitis.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
موانع الاستعمال
  • Known hypersensitivity to posaconazole or other azole antifungals.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Coadministration with sirolimus, CYP3A4 substrates pimozide or quinidine, HMG-CoA reductase inhibitors primarily metabolised by CYP3A4, ergot alkaloids, or venetoclax at initiation/ramp-up in CLL/SLL.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
تحذيرات واحتياطات
  • Calcineurin-inhibitor toxicity: posaconazole increases cyclosporine and tacrolimus concentrations; reduce their doses and monitor levels frequently.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • QTc prolongation and torsades de pointes; use with caution in proarrhythmic conditions; monitor and correct potassium, magnesium and calcium before and during therapy.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Hepatic toxicity: elevations in liver tests may occur; monitor liver tests and consider discontinuation if abnormal.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
التداخلات الدوائية
  • Cyclosporine / tacrolimusPosaconazole increases their concentrations; reduce doses and monitor levels frequently.DailyMed (U.S. National Library of Medicine)
  • SirolimusContraindicated: posaconazole increases sirolimus concentrations and toxicity.DailyMed (U.S. National Library of Medicine)
الحمل والرضاعة
  • Based on animal data, posaconazole may cause fetal harm; human data are insufficient to establish a drug-associated risk (skeletal malformations in rats at exposures above clinical levels).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • No human data; posaconazole is excreted in rat milk. Weigh breastfeeding benefits against maternal need and potential infant effects.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
المتابعة أثناء العلاج
  • Monitor electrolytes (K, Mg, Ca), liver tests, serum creatinine in renal impairment, and concentrations of interacting drugs such as cyclosporine or tacrolimus.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
كيف يعمل الدواء
  • Inhibits lanosterol 14-alpha-demethylase, blocking ergosterol synthesis in the fungal cell membrane.
سعر بوساكونكس 300مجم فيال للحقن الوريدي ببطء 16.7 ملالمثائل والبدائل

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