دواعي استعمال بريمارين كريم مهبلي 14 جرام

Premarin vaginal cream 14 gm (conjugated estrogens), Pfizer; listed on Egyptian price directories as an illegal (unregistered) import with price 0 EGP.

• Treatment of atrophic vaginitis and kraurosis vulvaeDailyMed (U.S. National Library of Medicine)
• Treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy due to menopauseDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions ≥2% in a controlled trial: headache, pelvic pain, vasodilation, breast pain, leucorrhea, metrorrhagia, vaginitis, vulvovaginal disorder.نشرة دولية لنفس المنتج · DailyMed (U.S. National Library of Medicine)

• Contraindicated with undiagnosed abnormal genital bleeding; breast cancer or history of breast cancer; estrogen-dependent neoplasia; active or history of DVT/PE; active or history of arterial thromboembolic disease; known anaphylaxis/angioedema to Premarin; hepatic impairment; protein C/S or antithrombin deficiency or other thrombophilic disorders.نشرة دولية لنفس المنتج · DailyMed (U.S. National Library of Medicine)

• Boxed warning: increased risk of endometrial cancer with unopposed estrogen in women with a uterus; estrogen-alone therapy should not be used to prevent cardiovascular disease or dementia; WHI reported increased stroke and DVT with oral conjugated estrogens. Systemic absorption occurs with vaginal cream; oral Premarin warnings apply.نشرة دولية لنفس المنتج · DailyMed (U.S. National Library of Medicine)

• CYP3A4 inducers/inhibitors (e.g. St John’s wort, phenobarbital, carbamazepine, rifampin; erythromycin, ketoconazole, ritonavir, grapefruit juice)Inducers may reduce estrogen levels; inhibitors may increase estrogen levels and side effects. No drug-interaction studies conducted specifically for Premarin vaginal cream.DailyMed (U.S. National Library of Medicine)

• Not indicated for use during pregnancy. Epidemiologic studies of combined hormonal contraceptives have not found an increased risk of major birth defects after early pregnancy exposure.نشرة دولية لنفس المنتج · DailyMed (U.S. National Library of Medicine)
• Estrogens are present in human milk and can reduce milk production; consider maternal need versus infant effects.نشرة دولية لنفس المنتج · DailyMed (U.S. National Library of Medicine)

• Mixture of conjugated estrogens that bind estrogen receptors and replace depleted endogenous estrogen in postmenopausal vaginal epithelium (US Premarin vaginal cream label).