دواعي استعمال بريمبران 10مجم 10 قرص

Metoclopramide 10 mg scored tablets, pack of 10 (Sanofi, Egypt).

• Treatment for 4 to 12 weeks of symptomatic, documented gastroesophageal reflux in adults who fail conventional therapy; relief of symptoms of acute and recurrent diabetic gastroparesis in adults.الفئة: AdultsDailyMed (U.S. NLM)

• Tardive dyskinesia, other extrapyramidal symptoms, neuroleptic malignant syndrome and depression are key labeled reactions; see full US label for common adverse reactions (restlessness, drowsiness).نشرة دولية لنفس التركيبة · DailyMed (U.S. NLM)

• History of tardive dyskinesia or dystonic reaction to metoclopramide; when GI motility stimulation might be dangerous (hemorrhage, mechanical obstruction, perforation); pheochromocytoma/catecholamine-releasing paraganglioma; epilepsy.نشرة دولية لنفس التركيبة · DailyMed (U.S. NLM)

• Boxed warning: tardive dyskinesia, potentially irreversible, increases with duration and total cumulative dose; avoid use longer than 12 weeks. Also EPS, neuroleptic malignant syndrome, depression/suicidal ideation.نشرة دولية لنفس التركيبة · DailyMed (U.S. NLM)

• AntipsychoticsPotential additive effects including tardive dyskinesia, EPS and NMS; avoid concomitant use.DailyMed (U.S. NLM)

• Published studies do not report an increased risk of adverse pregnancy outcomes with metoclopramide; potential neonatal risks after exposure during delivery. No adverse developmental effects in rats/rabbits at exposures about 6–12× MRHD.نشرة دولية لنفس التركيبة · DailyMed (U.S. NLM)
• Present in human milk in variable amounts; breastfed infants may have GI adverse reactions (discomfort, gas). Metoclopramide raises prolactin.نشرة دولية لنفس التركيبة · DailyMed (U.S. NLM)

• ميتوكلوبراميد: مضاد لمستقبلات الدوبامين D2 مع تأثير ناهض لـ5-HT4 ومضاد لـ5-HT3؛ محفز لحركة الجهاز الهضمي ومضاد للقيء.مضاد لمستقبلات الدوبامين D2