دواعي استعمال بروكورالان 5مجم 28 قرص

Ivabradine 5 mg film-coated tablets (Servier), a selective If-current inhibitor that lowers heart rate.

• Symptomatic treatment of chronic stable angina pectoris in adults with coronary artery disease, normal sinus rhythm and heart rate >= 70 bpm, who cannot take beta-blockers or are inadequately controlled on an optimal beta-blocker dose.الفئة: AdultsEuropean Medicines Agency
• Chronic heart failure NYHA II-IV with systolic dysfunction, in sinus rhythm with heart rate >= 75 bpm, combined with standard therapy including a beta-blocker or when beta-blockers are contraindicated or not tolerated.الفئة: AdultsEuropean Medicines Agency

• Very common: luminous phenomena (phosphenes). Common: bradycardia.نشرة دولية لنفس المنتج · European Medicines Agency
• Most common (>= 1%): bradycardia, hypertension, atrial fibrillation and luminous phenomena.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Resting heart rate below 70 bpm, very low blood pressure, cardiogenic shock, rhythm disorders, acute myocardial infarction, unstable or acute heart failure, unstable angina, severe liver problems; pregnancy, breastfeeding and women of childbearing potential without contraception; certain interacting medicines.نشرة دولية لنفس المنتج · European Medicines Agency
• Acute decompensated heart failure; clinically significant hypotension or bradycardia; sick sinus syndrome, sinoatrial block or third-degree AV block without a functioning demand pacemaker; severe hepatic impairment; pacemaker dependence; concomitant strong CYP3A4 inhibitors.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• May cause fetal toxicity; females of reproductive potential should use effective contraception.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Increases the risk of atrial fibrillation; monitor patients.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Monitor for heart-rate decreases and bradycardia symptoms; not recommended in second-degree AV block.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Strong CYP3A4 inhibitors (azole antifungals, macrolides such as clarithromycin, HIV protease inhibitors, nefazodone)Increase ivabradine levels; concomitant use contraindicated.DailyMed (U.S. National Library of Medicine)
• Moderate CYP3A4 inhibitors (e.g. diltiazem, verapamil)Avoid concomitant use.DailyMed (U.S. National Library of Medicine)
• CYP3A4 inducersDecrease ivabradine levels; avoid.DailyMed (U.S. National Library of Medicine)
• Negative chronotropes (e.g. digoxin, amiodarone, beta-blockers)Increased risk of bradycardia; monitor heart rate.DailyMed (U.S. National Library of Medicine)

• May cause fetal harm based on animal data (cardiac malformations in rats); no adequate human studies.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Must not be used during pregnancy or breastfeeding, or by women who could become pregnant and are not using appropriate contraception.نشرة دولية لنفس المنتج · European Medicines Agency
• Breastfeeding is not recommended.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Monitor heart rate, bradycardia symptoms and for atrial fibrillation during treatment.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Blocks the If current in the sinoatrial node, lowering heart rate and myocardial oxygen demand without affecting contractility.