دواعي استعمال بروجراف 0.5مجم 100 كبسولة

Tacrolimus 0.5 mg hard capsules (Prograf), calcineurin-inhibitor immunosuppressant used to prevent organ transplant rejection; pack of 100 capsules distributed in Egypt by Hikma.

• Prophylaxis of organ rejection in adult and pediatric recipients of allogeneic kidney, liver, heart or lung transplants, with other immunosuppressantsالفئة: Adults and pediatric patientsDailyMed (NLM)

• Most common (>=15%): abnormal renal function, hypertension, diabetes mellitus, fever, CMV infection, tremor, hyperglycemia, leukopenia, infection, anemia, constipation, diarrhea, headache, abdominal pain.نشرة دولية لنفس التركيبة · DailyMed (NLM)

• Hypersensitivity to tacrolimus (the injection is also contraindicated with hypersensitivity to polyoxyl 60 hydrogenated castor oil).نشرة دولية لنفس التركيبة · DailyMed (NLM)

• Boxed warning: increased risk of serious infections and malignancies (including lymphoma) that may lead to hospitalization or death.نشرة دولية لنفس التركيبة · DailyMed (NLM)
• Not interchangeable with extended-release tacrolimus products; risk of medication errors. Other warnings: new-onset diabetes after transplant, nephrotoxicity, neurotoxicity including PRES, hyperkalemia, hypertension, QT prolongation, avoid live vaccines, pure red cell aplasia.نشرة دولية لنفس التركيبة · DailyMed (NLM)

• Strong CYP3A inhibitors (e.g. nelfinavir) and grapefruit juiceIncrease tacrolimus concentrations; avoid or monitor trough levels and adjust dose.DailyMed (NLM)
• CYP3A4 inducersDecrease tacrolimus concentrations; monitor and adjust dose.DailyMed (NLM)
• Mycophenolic acid productsHigher MPA exposure than with cyclosporine; monitor MPA-related adverse reactions.DailyMed (NLM)

• Tacrolimus can cause fetal harm; in-utero exposure has been associated with prematurity, birth defects, low birth weight and fetal distress. A transplant pregnancy registry exists.نشرة دولية لنفس التركيبة · DailyMed (NLM)
• Tacrolimus has been reported in human milk; weigh benefits of breastfeeding against maternal need and potential infant effects.نشرة دولية لنفس التركيبة · DailyMed (NLM)

• Therapeutic drug monitoring of tacrolimus whole-blood trough concentrations is recommended; monitor blood glucose, serum potassium, renal function, blood pressure and neurological status.نشرة دولية لنفس التركيبة · DailyMed (NLM)

• Binds FKBP-12; the complex inhibits calcineurin, suppressing T-cell activation and interleukin-2 transcription.