دواعي استعمال برونتوجيست 200مجم لبوس مهبلي/شرجي

Progesterone 200 mg pessaries for vaginal or rectal use, pack of 30.

• Luteal phase support as part of Assisted Reproductive Technology (ART) treatmentالفئة: Womenelectronic medicines compendium (emc)
• Premenstrual syndrome, including premenstrual tension and depressionالفئة: Womenelectronic medicines compendium (emc)
• Puerperal depressionالفئة: Womenelectronic medicines compendium (emc)

• Common: somnolence, abdominal pain/discomfort, breast pain; in ART also abdominal distension, constipation, hot flush and fatigue. Diarrhoea and flatulence may occur with rectal use; local soreness and leakage of the pessary base.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc)

• Hypersensitivity; undiagnosed vaginal bleeding; known or suspected progesterone-sensitive malignant tumours; porphyria; severe hepatic dysfunction; known missed abortion or ectopic pregnancy; active or past arterial/venous thromboembolism or severe thrombophlebitis.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc)

• Not indicated in threatened miscarriage; discontinue if myocardial infarction, cerebrovascular disorder, thromboembolism, thrombophlebitis or retinal thrombosis is suspected.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc)
• Observe patients with a history of depression, conditions affected by fluid retention (epilepsy, migraine, asthma, cardiac or renal dysfunction) and diabetes; use with caution in hepatic dysfunction.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc)

• CYP3A4 inducers (e.g. rifampicin, carbamazepine, phenytoin)May increase elimination and decrease bioavailability of progesterone.electronic medicines compendium (emc)
• Other vaginal productsEffect on progesterone exposure not assessed; concomitant use not recommended.electronic medicines compendium (emc)

• Should not be used in pregnancy except during the first trimester as part of ART; data on congenital anomalies after intrauterine exposure are limited and inconclusive.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc)
• Progesterone is excreted in human milk; should not be used during breast-feeding.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc)

• With adequate estrogen, transforms proliferative into secretory endometrium; increases endometrial receptivity and maintains pregnancy.