سعر بروبيس 10مجم غسول مهبلي 2022

Dinoprostone (prostaglandin E2) 10 mg vaginal delivery system releasing about 0.3 mg/hour, for cervical ripening at term.

• Initiation of cervical ripening at term (from 37 completed weeks of gestation)Population: Pregnant women at termelectronic medicines compendium (emc)

• Most common: fetal heart rate disorder, abnormal uterine contractions and abnormal labour affecting the fetus; also uterine hyperstimulation/tachysystole, nausea, vomiting, hypotension; post-marketing DIC, anaphylaxis and uterine rupture.International label, same product · electronic medicines compendium (emc)
• Most common (≥2%) with the US 10 mg insert: uterine tachysystole with or without fetal distress, and fetal distress without tachysystole.International label, same formulation · DailyMed (US NLM)

• Labour started; oxytocic or other induction agents being given; previous major uterine or cervical surgery (e.g. caesarean section); cephalopelvic disproportion; fetal malpresentation; suspected fetal distress; untreated pelvic inflammatory disease; hypersensitivity; placenta praevia or unexplained vaginal bleeding.International label, same product · electronic medicines compendium (emc)

• Uterine rupture reported, mainly with contraindicated conditions; caution with history of uterine hypertonus, glaucoma, asthma, ruptured membranes, multiple pregnancy, >3 full-term deliveries; increased DIC risk in women ≥35 years or with pregnancy complications; stop NSAIDs including aspirin before use.International label, same product · electronic medicines compendium (emc)

• Oxytocic drugs (e.g. oxytocin)Prostaglandins potentiate the uterotonic effect of oxytocics; do not use concurrently.electronic medicines compendium (emc)

• Should not be used before 37 completed weeks of gestation.International label, same product · electronic medicines compendium (emc)
• May pass into colostrum/breast milk at very limited levels; not expected to hinder breastfeeding.International label, same product · electronic medicines compendium (emc)

• Dinoprostone: PGE2 promotes cervical ripening (collagenase activation and collagen breakdown), transforming the cervix from rigid to soft and dilated.