دواعي استعمال بروبايلثيويوراسيل 50مجم 20 اقراص

Propylthiouracil 50 mg tablets (BP) by Memphis (Egypt), a thioamide antithyroid drug.

• Hyperthyroidism due to Graves' disease or toxic multinodular goitre in patients intolerant of methimazole and for whom surgery or radioactive iodine is not appropriateDailyMed (U.S. National Library of Medicine)
• Amelioration of hyperthyroid symptoms in preparation for thyroidectomy or radioactive iodine therapy in patients intolerant of methimazoleDailyMed (U.S. National Library of Medicine)

• Hypersensitivity to propylthiouracil or any product component.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)

• Boxed warning: severe liver injury and acute liver failure, sometimes fatal or requiring transplantation, in adults and children; reserve for patients who cannot tolerate methimazole and for whom radioactive iodine or surgery are not appropriate.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
• Agranulocytosis in about 0.2-0.5% of patients, typically within the first 3 months; report fever or sore throat immediately; leukopenia, thrombocytopenia and aplastic anaemia may also occur.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)

• Liver failure and death have been reported in women treated during pregnancy; PTU crosses the placenta and can cause fetal goitre and cretinism. The US label notes PTU may be the treatment of choice when an antithyroid drug is needed during or just before the first trimester.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)

• Monitor for symptoms of liver injury and of agranulocytosis (fever, sore throat); discontinue if agranulocytosis or aplastic anaemia is suspected.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)

• Inhibits thyroid hormone synthesis (thyroid peroxidase inhibition), per Dawa Prices pharmacology text.