دواعي استعمال بيورينول 300مجم كبسول

Allopurinol 300 mg sustained-release capsules (Hikma Pharma, Egypt); xanthine oxidase inhibitor for hyperuricaemia/gout.

• Primary or secondary goutالفئة: AdultsDailyMed (U.S. National Library of Medicine)
• Hyperuricaemia from cancer therapy in leukaemia, lymphoma and solid tumoursالفئة: Adults and childrenDailyMed (U.S. National Library of Medicine)
• Recurrent calcium oxalate calculi with hyperuricosuriaالفئة: AdultsDailyMed (U.S. National Library of Medicine)

• Most common (>1%): diarrhoea, nausea, raised liver enzymes/alkaline phosphatase, acute gout attacks, rash.معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)

• History of hypersensitivity to allopurinol or any ingredient.معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)

• Serious, sometimes fatal skin and hypersensitivity reactions (SJS/TEN, DRESS); stop at the first rash. HLA-B*58:01 carriers are at higher risk.معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)
• Gout flares may occur on initiation (prophylaxis with colchicine or an anti-inflammatory is recommended); nephrotoxicity, reversible hepatotoxicity and myelosuppression have been reported; drowsiness may affect driving.معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)

• Mercaptopurine or azathioprineAllopurinol 300-600 mg/day requires reducing mercaptopurine/azathioprine to about one-third to one-quarter of the usual dose.DailyMed (U.S. National Library of Medicine)
• Warfarin / dicumarolMay enhance anticoagulant effect; monitor INR/prothrombin time.DailyMed (U.S. National Library of Medicine)
• Capecitabine; pegloticaseAvoid allopurinol with capecitabine; do not use with pegloticase.DailyMed (U.S. National Library of Medicine)
• Ampicillin, amoxicillin, bendamustine, thiazide diureticsMay increase the risk of skin rash, which may be severe.DailyMed (U.S. National Library of Medicine)

• Based on animal findings may cause fetal harm; limited human data show no clear pattern of adverse outcomes.معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)
• Allopurinol and oxypurinol are present in human milk; advise not to breastfeed during treatment and for one week after the last dose.معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)

• Baseline serum uric acid, CBC, chemistry, liver and kidney function; monitor kidney function early in therapy.معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)

• Structural analogue of hypoxanthine that inhibits xanthine oxidase (with its metabolite oxypurinol), reducing uric acid formation (US label).