دواعي استعمال بيرال 500مجم 20 قرص

Paracetamol 500 mg tablet (20 tablets (2 strips x 10)) by Kahira Pharmaceuticals and Chemical Industries, Egypt.

• Mild to moderate pain (headache incl. migraine and tension headache, toothache, backache, rheumatic and muscle pain, dysmenorrhoea, sore throat) and fever, including colds and fluالفئة: Adults and children 10 years and overelectronic medicines compendium (emc)

• Very rare: thrombocytopenia, agranulocytosis, anaphylaxis, skin hypersensitivity reactions including serious skin reactions, bronchospasm (mainly in aspirin/NSAID-sensitive asthmatics), hepatic dysfunction; HAGMA frequency not known.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)

• Hypersensitivity to paracetamol or any other ingredient; do not combine with other paracetamol-containing medicines.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)

• Do not exceed the stated dose: overdose can cause delayed, serious liver damage; seek medical help at once after overdose even if well.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• Use with care in severe renal or hepatic impairment; overdose hazards are greater in non-cirrhotic alcoholic liver disease.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• High anion gap metabolic acidosis due to pyroglutamic acidosis has been reported with prolonged therapeutic use in severe illness, malnutrition or glutathione deficiency, or with flucloxacillin.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)

• Warfarin and other coumarinsChronic paracetamol use may enhance the anticoagulant effect with increased bleeding risk; occasional doses have no significant effect.electronic medicines compendium (emc)
• ColestyramineReduces paracetamol absorption; do not take within one hour if maximal analgesia is required.electronic medicines compendium (emc)
• Metoclopramide, domperidoneAccelerate paracetamol absorption; concurrent use need not be avoided.electronic medicines compendium (emc)
• FlucloxacillinConcurrent use associated with high anion gap metabolic acidosis, especially with risk factors.electronic medicines compendium (emc)
• AlcoholReduces liver capacity to handle paracetamol.electronic medicines compendium (emc)

• Large amounts of data indicate neither malformative nor feto/neonatal toxicity; neurodevelopment data are inconclusive. If clinically needed, use the lowest effective dose for the shortest time at the lowest frequency.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• Excreted in breast milk but not in clinically significant quantities; published data do not contraindicate breastfeeding.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)

• Probably acts mainly by inhibiting prostaglandin synthesis in the CNS; antipyretic action on the hypothalamic heat-regulating centre (UK SmPC).