دواعي استعمال بيرال اكسترا 20 قرص

Paracetamol + caffeine tablets, box of 20 tablets (2 strips); analgesic/antipyretic for headache and pain (Kahira, Egypt). Strengths not stated by the opened source.

• Mild analgesic and antipyretic for painful and febrile conditions, e.g. headache including migraine, backache, toothache, rheumatic pain, dysmenorrhoea, and symptoms of colds, influenza and sore throat.electronic medicines compendium (emc)

• Very rare post-marketing: thrombocytopenia, agranulocytosis, anaphylaxis, skin hypersensitivity including serious skin reactions, bronchospasm, hepatic dysfunction; caffeine-related dizziness, headache, palpitations, insomnia, restlessness, anxiety, GI disturbance.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc)

• Hypersensitivity to paracetamol, caffeine or any other constituent.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc)

• Do not use with other paracetamol-containing products; overdose may cause liver failure. Care in renal or hepatic impairment; greater hazard in non-cirrhotic alcoholic liver disease.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc)
• High anion gap metabolic acidosis due to pyroglutamic acidosis has been reported with prolonged therapeutic use in at-risk patients (severe illness, malnutrition, chronic alcoholism) or with flucloxacillin.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc)
• Avoid excessive caffeine intake (coffee, tea, some canned drinks) while taking this product.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc)

• Warfarin and other coumarinsAnticoagulant effect may be enhanced by prolonged regular daily paracetamol use.electronic medicines compendium (emc)
• Metoclopramide / domperidone; colestyramineParacetamol absorption may be increased by metoclopramide or domperidone and reduced by colestyramine.electronic medicines compendium (emc)
• LithiumCaffeine may increase lithium clearance; concomitant use not recommended.electronic medicines compendium (emc)
• FlucloxacillinConcomitant use associated with high anion gap metabolic acidosis due to pyroglutamic acidosis.electronic medicines compendium (emc)

• Paracetamol-caffeine is not recommended during pregnancy because of a possible increased risk of lower birth weight and spontaneous abortion associated with caffeine.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc)
• Caffeine in breast milk may have a stimulating effect on breast-fed infants; should not be used while breast feeding.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc)