دواعي استعمال بيرازيد 500مجم 10 اقراص

Pyrazinamide 500 mg tablets, Box of 10 tablets (1 strip); antitubercular agent (El Nasr, Egypt).

• Initial treatment of active tuberculosis in adults and children when combined with other antituberculous agents; also after treatment failure with other primary drugs.DailyMed (U.S. National Library of Medicine)

• Principal adverse effect is dose-related hepatotoxicity; also nausea, vomiting, anorexia, gout, frequent mild arthralgia and myalgia, rashes, urticaria, pruritus; rarely thrombocytopenia, sideroblastic anaemia, fever, photosensitivity, porphyria, dysuria, interstitial nephritis.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Severe hepatic damage; hypersensitivity to pyrazinamide; acute gout.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Obtain baseline serum uric acid and liver function; follow closely patients with liver disease or at risk of drug-related hepatitis; discontinue permanently if hepatocellular damage or hyperuricemia with acute gouty arthritis appears.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Inhibits renal urate excretion, frequently causing (usually asymptomatic) hyperuricemia; use with caution in diabetes mellitus.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• No animal reproduction studies; unknown whether it can cause fetal harm; give to a pregnant woman only if clearly needed.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Found in small amounts in breast milk; use with caution in nursing mothers weighing risk and benefit.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Baseline serum uric acid and liver function tests; close follow-up in patients with liver disease.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)