دواعي استعمال كاندوفيرال 200مجم 40 قرص

Favipiravir 200 mg film-coated tablets, box of 40 (4 strips); antiviral (Penta Pharma, Egypt).

• Novel or re-emerging influenza virus infections, limited to cases where other anti-influenza agents are not effective or insufficiently effective, and only when the government decides to use it.BfArM (hosting English translation of the Japanese prescribing information)

• In Japanese and global studies (lower doses): blood uric acid increase (4.79%), diarrhoea (4.79%), neutrophil decrease (1.80%), AST increase (1.80%), ALT increase (1.60%). Clinically significant reactions reported with similar drugs include shock/anaphylaxis, pneumonia, fulminant hepatitis, TEN/SJS, acute kidney injury and blood count decreases.نشرة دولية لنفس التركيبة · BfArM (hosting English translation of the Japanese prescribing information)

• Women known or suspected to be pregnant (early embryonic deaths and teratogenicity in animal studies).نشرة دولية لنفس التركيبة · BfArM (hosting English translation of the Japanese prescribing information)
• History of hypersensitivity to any ingredient of the drug.نشرة دولية لنفس التركيبة · BfArM (hosting English translation of the Japanese prescribing information)

• Before treating women of child-bearing potential, confirm a negative pregnancy test; use effective contraception during and for 7 days after treatment.نشرة دولية لنفس التركيبة · BfArM (hosting English translation of the Japanese prescribing information)
• Favipiravir is distributed in sperm: men must use effective contraception (condom) during and for 7 days after treatment and avoid intercourse with pregnant women.نشرة دولية لنفس التركيبة · BfArM (hosting English translation of the Japanese prescribing information)
• Abnormal behaviour (risk of falls) has been reported in influenza patients regardless of antiviral used; caution in gout or hyperuricaemia (uric acid may increase).نشرة دولية لنفس التركيبة · BfArM (hosting English translation of the Japanese prescribing information)

• PyrazinamideBlood uric acid increases; additive enhancement of uric acid reabsorption in the renal tubule.BfArM (hosting English translation of the Japanese prescribing information)
• RepaglinideRepaglinide blood levels may increase (CYP2C8 inhibition).BfArM (hosting English translation of the Japanese prescribing information)
• TheophyllineFavipiravir levels may increase and adverse reactions may occur (xanthine oxidase interaction).BfArM (hosting English translation of the Japanese prescribing information)
• Famciclovir, sulindacEfficacy of these drugs may be reduced (aldehyde oxidase inhibition).BfArM (hosting English translation of the Japanese prescribing information)

• Contraindicated in known or suspected pregnancy; early embryonic deaths and teratogenicity observed in animals.نشرة دولية لنفس التركيبة · BfArM (hosting English translation of the Japanese prescribing information)

• Favipiravir triphosphate (formed intracellularly) inhibits the viral RNA polymerase; favipiravir is metabolised mainly by aldehyde oxidase and partly by xanthine oxidase, and inhibits AO and CYP2C8.