دواعي استعمال كواديل 100مجم 20 اقراص

Quetiapine 100 mg film-coated tablets, pack of 20; atypical antipsychotic (Delta Pharma, Egypt).

• Schizophrenia (adults and adolescents 13-17 years)الفئة: Adults; adolescents 13-17 yearsDailyMed (NLM)
• Bipolar I disorder: acute manic episodes, as monotherapy or adjunct to lithium or divalproexالفئة: Adults; children/adolescents 10-17 years (monotherapy)DailyMed (NLM)
• Bipolar disorder: acute depressive episodes (monotherapy)الفئة: AdultsDailyMed (NLM)

• Serious adverse reactions discussed in the label include cerebrovascular events in elderly dementia patients, neuroleptic malignant syndrome, metabolic changes (hyperglycaemia, dyslipidaemia, weight gain), tardive dyskinesia, hypotension, falls and blood pressure increases in children and adolescents.نشرة دولية لنفس التركيبة · DailyMed (NLM)

• Known hypersensitivity to quetiapine or to any excipient of the formulation (anaphylactic reactions have been reported).نشرة دولية لنفس التركيبة · DailyMed (NLM)

• Boxed warning: increased mortality in elderly patients with dementia-related psychosis treated with antipsychotics; quetiapine is not approved for dementia-related psychosis.نشرة دولية لنفس التركيبة · DailyMed (NLM)
• Boxed warning: antidepressants increased the risk of suicidal thoughts and behaviours in children, adolescents and young adults in short-term studies; monitor closely for clinical worsening and emergence of suicidal thoughts.نشرة دولية لنفس التركيبة · DailyMed (NLM)

• Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)Reduce the quetiapine dose to one sixth when co-administered.DailyMed (NLM)
• Strong CYP3A4 inducers (e.g., phenytoin, rifampin, St John's wort)Increase quetiapine dose up to 5-fold with chronic (>7-14 days) inducer treatment; reduce by 5-fold within 7-14 days after the inducer is stopped.DailyMed (NLM)
• Alcohol and other centrally acting drugsQuetiapine potentiated the cognitive and motor effects of alcohol; use caution with other CNS-active drugs and limit alcohol.DailyMed (NLM)

• Published epidemiologic data have not established a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes; untreated psychiatric illness carries maternal risk. A pregnancy exposure registry for atypical antipsychotics exists.نشرة دولية لنفس التركيبة · DailyMed (NLM)
• Limited published data show quetiapine in human milk at a relative infant dose below 1% of the maternal weight-adjusted dose, with no consistent adverse effects reported in breastfed infants; weigh benefits against risks.نشرة دولية لنفس التركيبة · DailyMed (NLM)