دواعي استعمال كوادروستار 10 اقراص

Four-drug fixed-dose combination tablet (rifampicin, isoniazid, pyrazinamide, ethambutol) for tuberculosis; pack of 10 tablets.

• Initial (intensive-phase) treatment of tuberculosis due to Mycobacterium tuberculosis, per current WHO guidelinesالفئة: Adults and children weighing 25 kg or moreWHO Prequalification Unit

• Hypersensitivity to rifamycins, isoniazid, pyrazinamide, ethambutol or excipients; history of drug-induced hepatitis or acute liver disease; porphyria; acute gouty arthritis; severe renal impairment (CrCl < 30 mL/min); concomitant voriconazole or HIV/HCV protease inhibitors.نشرة دولية لتركيبة مكافئة · WHO Prequalification Unit

• Withdraw immediately on severe hypersensitivity (thrombocytopenia, purpura, haemolytic anaemia, dyspnoea, shock, renal failure) and never re-treat with rifampicin; ethambutol requires ocular examination (acuity, colour vision, visual fields) before and during treatment.نشرة دولية لتركيبة مكافئة · WHO Prequalification Unit

• Can be used in pregnancy if benefits outweigh risks; TB treatment in pregnancy is the same as in non-pregnant women.نشرة دولية لتركيبة مكافئة · WHO Prequalification Unit
• All four drugs appear in breast milk at low concentrations; can be used during breast-feeding.نشرة دولية لتركيبة مكافئة · WHO Prequalification Unit

• Ophthalmological examination before and periodically during treatment; question patients about vision at each visit.نشرة دولية لتركيبة مكافئة · WHO Prequalification Unit