دواعي استعمال رابيبرازول 10مجم 7 اقراص

Rabeprazole sodium 10 mg enteric-coated (gastro-resistant) tablets, a proton pump inhibitor; 7 enteric-coated tablets.

• Active duodenal ulcerالفئة: Adultselectronic medicines compendium (emc)
• Active benign gastric ulcerالفئة: Adultselectronic medicines compendium (emc)
• Symptomatic erosive or ulcerative gastro-oesophageal reflux disease (GORD)الفئة: Adultselectronic medicines compendium (emc)
• Long-term management of GORD (maintenance)الفئة: Adultselectronic medicines compendium (emc)
• Symptomatic treatment of moderate to very severe GORDالفئة: Adultselectronic medicines compendium (emc)
• Zollinger-Ellison syndromeالفئة: Adultselectronic medicines compendium (emc)
• Eradication of Helicobacter pylori in peptic ulcer disease, with appropriate antibacterial regimensالفئة: Adultselectronic medicines compendium (emc)

• Most commonly reported in clinical trials: headache, diarrhoea, abdominal pain, asthenia, flatulence, rash and dry mouth, mostly mild or moderate and transient.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)

• Hypersensitivity to rabeprazole or any excipient.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• Contraindicated during breast-feeding.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• Contraindicated with rilpivirine-containing products; hypersensitivity to substituted benzimidazoles.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)

• Exclude gastric or oesophageal malignancy before treatment, as symptomatic response does not preclude it.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• Long-term PPI use may modestly increase the risk of hip, wrist and spine fractures, and severe hypomagnesaemia has been reported after at least 3 months of treatment.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• PPIs may increase the risk of gastrointestinal infections such as Salmonella, Campylobacter and Clostridium difficile.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• Acute tubulointerstitial nephritis may occur at any time; discontinue rabeprazole if suspected.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• Long-term use may reduce vitamin B12 absorption; very infrequent cases of subacute cutaneous lupus erythematosus have been reported with PPIs.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• Stop treatment at least 5 days before chromogranin A measurement, as raised CgA may interfere with neuroendocrine tumour investigations.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)

• AtazanavirCo-administration not recommended: PPIs substantially reduce atazanavir exposure.electronic medicines compendium (emc)
• Ketoconazole / itraconazoleReduced antifungal plasma levels; monitor and adjust dose if needed.electronic medicines compendium (emc)
• Methotrexate (high dose)PPIs may raise and prolong methotrexate levels; temporary PPI withdrawal may be considered.electronic medicines compendium (emc)

• Over 1000 exposed pregnancy outcomes do not indicate an increased risk of major malformations; animal studies showed reproductive toxicity; use in pregnancy only if benefit outweighs uncertainty.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• No available human data on rabeprazole in pregnancy to inform drug-associated risk; no adverse developmental effects in rat and rabbit studies.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
• Not known whether excreted in human milk; excreted in rat milk; should not be used during breast-feeding.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)

• Consider measuring magnesium before and periodically during prolonged treatment, or with digoxin or diuretics; keep long-term patients under regular surveillance.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)