دواعي استعمال راميبريل كومب ال اس 2.5/12.5مجم 7 اقراص

Ramipril 2.5 mg + hydrochlorothiazide 12.5 mg tablets by Pharopharma (Egypt), a fixed-dose antihypertensive combination.

• Treatment of hypertension in patients whose blood pressure is not adequately controlled with ramipril alone or hydrochlorothiazide alone.الفئة: AdultsSwedish Medical Products Agency (Läkemedelsverket, MPA)

• Common: headache, dizziness; persistent dry cough (ramipril).نشرة دولية لنفس التركيبة · Swedish Medical Products Agency (Läkemedelsverket, MPA)
• Other reported effects include myocardial ischaemia, tachycardia, palpitations, blood-count decreases, visual disturbance, and (not known frequency) non-melanoma skin cancer with hydrochlorothiazide.نشرة دولية لنفس التركيبة · Swedish Medical Products Agency (Läkemedelsverket, MPA)

• Hypersensitivity to ramipril, other ACE inhibitors, hydrochlorothiazide, other thiazides, sulphonamides or excipients.نشرة دولية لنفس التركيبة · Swedish Medical Products Agency (Läkemedelsverket, MPA)
• History of angioedema (hereditary, idiopathic or with ACE inhibitors/AIIRAs).نشرة دولية لنفس التركيبة · Swedish Medical Products Agency (Läkemedelsverket, MPA)
• Significant bilateral renal artery stenosis or stenosis in a single functioning kidney; severe renal impairment (CrCl <30 mL/min) in undialysed patients.نشرة دولية لنفس التركيبة · Swedish Medical Products Agency (Läkemedelsverket, MPA)
• Second and third trimesters of pregnancy; lactation.نشرة دولية لنفس التركيبة · Swedish Medical Products Agency (Läkemedelsverket, MPA)
• Clinically relevant electrolyte disturbances; severe hepatic impairment; hepatic encephalopathy.نشرة دولية لنفس التركيبة · Swedish Medical Products Agency (Läkemedelsverket, MPA)
• Aliskiren-containing products in diabetes or renal impairment (GFR <60 mL/min/1.73 m2); sacubitril/valsartan (wait 36 hours).نشرة دولية لنفس التركيبة · Swedish Medical Products Agency (Läkemedelsverket, MPA)
• Extracorporeal treatments bringing blood into contact with negatively charged surfaces.نشرة دولية لنفس التركيبة · Swedish Medical Products Agency (Läkemedelsverket, MPA)

• Serious adverse reactions include angioedema or anaphylactic reactions, renal or hepatic impairment, pancreatitis, severe skin reactions and neutropenia/agranulocytosis.نشرة دولية لنفس التركيبة · Swedish Medical Products Agency (Läkemedelsverket, MPA)
• Hydrochlorothiazide may worsen glucose, lipid and uric acid metabolism; the two components have opposite effects on plasma potassium.نشرة دولية لنفس التركيبة · Swedish Medical Products Agency (Läkemedelsverket, MPA)
• Hypotension may occur at initiation in diuretic-treated patients; consider reducing or stopping the diuretic first.نشرة دولية لنفس التركيبة · Swedish Medical Products Agency (Läkemedelsverket, MPA)

• Contraindicated during breast-feeding; both substances are excreted in human milk and thiazides may suppress lactation.نشرة دولية لنفس التركيبة · Swedish Medical Products Agency (Läkemedelsverket, MPA)