دواعي استعمال Ramiril 5 mg 7 h.g. caps

Ramiril 5 mg hard gelatin capsules (ramipril) by Kahira Pharmaceuticals (Egypt), an ACE-inhibitor antihypertensive.

• Treatment of hypertension, to lower blood pressure (alone or with thiazide diuretics).الفئة: AdultsDailyMed (U.S. National Library of Medicine)
• Reduction of the risk of myocardial infarction, stroke or death from cardiovascular causes in patients 55 years or older at high cardiovascular risk.الفئة: Adults 55 years and olderDailyMed (U.S. National Library of Medicine)
• Stable patients with clinical signs of congestive heart failure in the first days after acute myocardial infarction.الفئة: AdultsDailyMed (U.S. National Library of Medicine)

• Most common in hypertension trials: headache, dizziness, fatigue/asthenia and cough.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Heart failure post-MI (AIRE): hypotension, increased cough, dizziness, angina, nausea, postural hypotension, syncope, vomiting, vertigo, abnormal kidney function, diarrhea.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to ramipril or any other ACE inhibitor, including angioedema during previous ACE-inhibitor therapy; history of hereditary or idiopathic angioedema.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Combination with a neprilysin inhibitor (e.g. sacubitril); do not give within 36 hours of switching to or from sacubitril/valsartan.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Co-administration with aliskiren in patients with diabetes.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Angioedema (head, neck or intestinal) may occur at any time; discontinue and treat promptly; higher risk with mTOR or neprilysin inhibitors.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Symptomatic hypotension, especially in volume- or salt-depleted patients; correct depletion before starting.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Renal impairment and hyperkalemia may occur; monitor renal function and serum potassium in at-risk patients.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Rare cholestatic jaundice progressing to hepatic failure; discontinue if jaundice or marked liver-enzyme elevation occurs.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Rare neutropenia/agranulocytosis, mainly in collagen-vascular disease with renal impairment.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Avoid dual blockade of the renin-angiotensin system (ACE inhibitor + ARB or aliskiren).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Persistent non-productive cough may occur with ACE inhibitors.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• DiureticsPossible excessive hypotension at initiation; reduce or stop diuretic or lower the starting dose.DailyMed (U.S. National Library of Medicine)
• Potassium supplements, salt substitutes, potassium-sparing diureticsRisk of hyperkalemia; monitor serum potassium.DailyMed (U.S. National Library of Medicine)
• LithiumIncreased serum lithium and toxicity; monitor lithium levels frequently.DailyMed (U.S. National Library of Medicine)
• NSAIDs including COX-2 inhibitorsMay worsen renal function and attenuate the antihypertensive effect.DailyMed (U.S. National Library of Medicine)
• Aliskiren / angiotensin receptor blockersDual RAS blockade increases hypotension, hyperkalemia and renal impairment; avoid.DailyMed (U.S. National Library of Medicine)
• Injectable gold (sodium aurothiomalate)Nitritoid reactions reported.DailyMed (U.S. National Library of Medicine)
• mTOR inhibitors (e.g. temsirolimus) and neprilysin inhibitorsIncreased risk of angioedema.DailyMed (U.S. National Library of Medicine)

• Boxed warning: drugs acting on the renin-angiotensin system can cause injury and death to the developing fetus; discontinue ramipril as soon as possible when pregnancy is detected.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Because multiple doses may produce low, unpredictable milk concentrations, ramipril should not be used in nursing mothers.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Establish baseline renal function; monitor renal function, serum potassium and blood pressure, and consider white-cell counts in collagen-vascular disease.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)