دواعي استعمال Ranxapin 10 mg 10 tabs.

Olanzapine 10 mg tablets (Ranxapin, Future Pharmaceutical Industries > Sun Pharma Egypt); the 10-tablet pack named in the source file was not found in the directories opened (7- and 21-tablet packs are listed).

• Schizophrenia, including maintaining clinical improvement during continuation therapy in initial responders.الفئة: Adultselectronic medicines compendium (emc)
• Moderate to severe manic episode.الفئة: Adultselectronic medicines compendium (emc)
• Prevention of recurrence in bipolar disorder in patients whose manic episode responded to olanzapine.الفئة: Adultselectronic medicines compendium (emc)

• Very common: weight gain, somnolence, orthostatic hypotension, elevated plasma prolactin.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• Common: eosinophilia, leukopenia, neutropenia, elevated cholesterol, glucose and triglycerides, glucosuria, increased appetite, dizziness, akathisia, parkinsonism, dyskinesia, mild anticholinergic effects (constipation, dry mouth), transient raised ALT/AST, rash, asthenia, fatigue, oedema, pyrexia, arthralgia, sexual dysfunction.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• Uncommon/rare: diabetes with ketoacidosis or coma, seizures, tardive dyskinesia, bradycardia, QTc prolongation, thromboembolism, photosensitivity, alopecia, urinary incontinence/retention; NMS, pancreatitis, hepatitis, rhabdomyolysis, ventricular arrhythmias/sudden death, DRESS (not known).نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)

• Hypersensitivity to olanzapine or any excipient.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• Patients with known risk of narrow-angle glaucoma.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)

• Not recommended in dementia-related psychosis and/or behavioural disturbances: increased mortality and cerebrovascular adverse events in elderly patients.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• Neuroleptic malignant syndrome: discontinue all antipsychotics if signs develop.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• Hyperglycaemia/diabetes (occasionally with ketoacidosis or coma), weight gain and adverse lipid changes: monitor glucose, weight and lipids.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• Caution in prostatic hypertrophy, paralytic ileus, elevated liver enzymes or hepatic impairment, low leukocyte/neutrophil counts, seizure history, QT-prolonging drugs or cardiac risk factors; risk of tardive dyskinesia, postural hypotension, venous thromboembolism and sudden cardiac death.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• Not recommended for dopamine-agonist-associated psychosis in Parkinson's disease. May cause somnolence and dizziness: caution when driving or operating machinery.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)

• Fluvoxamine, ciprofloxacin and other CYP1A2 inhibitorsIncrease olanzapine levels (fluvoxamine raised AUC by 52-108%); consider a lower starting dose.electronic medicines compendium (emc)
• Smoking, carbamazepine (CYP1A2 inducers)May reduce olanzapine concentrations; monitor and consider dose increase.electronic medicines compendium (emc)
• Activated charcoalReduces oral bioavailability by 50-60%; separate by at least 2 hours.electronic medicines compendium (emc)
• Dopamine agonists / levodopaOlanzapine may antagonise their effects.electronic medicines compendium (emc)
• Alcohol and CNS depressantsAdditive CNS effects; use caution.electronic medicines compendium (emc)
• QTc-prolonging drugsUse caution with concomitant medicines known to increase QTc.electronic medicines compendium (emc)
• ValproateNeutropenia reported commonly with concomitant use.electronic medicines compendium (emc)

• No adequate and well-controlled studies in pregnant women; use only if potential benefit justifies the potential risk to the foetus.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• Excreted in breast milk (infant exposure about 1.8% of the maternal weight-adjusted dose); patients should not breast-feed while taking olanzapine.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)

• Blood glucose at baseline, 12 weeks after starting and annually; weight at baseline, 4, 8 and 12 weeks then quarterly; lipids at baseline, 12 weeks and every 5 years.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)
• Periodic blood pressure measurement in patients over 65 years; follow-up of ALT/AST where elevated.نشرة دولية لنفس التركيبة · electronic medicines compendium (emc)

• Broad receptor profile with affinity for serotonin 5-HT2A/2C, 5-HT3, 5-HT6, dopamine D1-D5, muscarinic M1-M5, alpha-1 adrenergic and histamine H1 receptors; greater 5-HT2 than D2 activity (UK SmPC).