دواعي استعمال راباميون 1مجم 30 قرص

Sirolimus 1 mg sugar-coated tablets (mTOR inhibitor immunosuppressant), pack of 30 tablets (3 strips).

• Prophylaxis of organ rejection in renal transplant patients aged 13 years and olderDailyMed (U.S. National Library of Medicine)

• Hypersensitivity to sirolimus.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)

• Boxed warning: immunosuppression increases susceptibility to infection and possible development of lymphoma and other malignancies; use is not recommended in liver or lung transplant patients.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
• Warnings include hypersensitivity, angioedema, fluid accumulation and impaired wound healing, hyperlipidaemia, decline in renal function, proteinuria, latent viral infections and interstitial lung disease.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)

• Strong CYP3A4/P-gp inhibitors or inducersSirolimus is a CYP3A4 and P-gp substrate; avoid concomitant use with strong inhibitors or inducers.DailyMed (U.S. National Library of Medicine)

• Based on animal studies and mechanism of action, sirolimus can cause fetal harm; human data are limited.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)
• Unknown whether sirolimus is present in human milk; it is present in rat milk and there is potential for serious adverse effects in breastfed infants.نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)

• Monitor lipids, renal function and proteinuria during therapy (per warnings on hyperlipidaemia, renal function decline and proteinuria).نشرة دولية لتركيبة مكافئة · DailyMed (U.S. National Library of Medicine)