دواعي استعمال راسبيلوسين ٤٠٠ مجم ١٠ أقراص 400 مجم

Moxifloxacin 400 mg film-coated tablets, a fluoroquinolone antibacterial; pack of 10 tablets (Organo Pharma, Egypt).

• Community-acquired pneumonia caused by susceptible bacteriaالفئة: AdultsDailyMed (U.S. National Library of Medicine)
• Uncomplicated and complicated skin and skin structure infectionsالفئة: AdultsDailyMed (U.S. National Library of Medicine)
• Complicated intra-abdominal infectionsالفئة: AdultsDailyMed (U.S. National Library of Medicine)
• Plague (treatment and prophylaxis)الفئة: AdultsDailyMed (U.S. National Library of Medicine)
• Acute bacterial sinusitis (only when no alternative treatment options)الفئة: AdultsDailyMed (U.S. National Library of Medicine)
• Acute bacterial exacerbation of chronic bronchitis (only when no alternative treatment options)الفئة: AdultsDailyMed (U.S. National Library of Medicine)

• Most common (3% or more): nausea, diarrhoea, headache and dizziness.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• History of hypersensitivity to moxifloxacin or any other quinolone antibacterial.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Boxed warning: disabling and potentially irreversible serious reactions including tendinitis/tendon rupture, peripheral neuropathy and CNS effects; discontinue immediately and avoid fluoroquinolones in patients who experience them.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• May exacerbate muscle weakness in myasthenia gravis; avoid in patients with a history of myasthenia gravis.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• QT prolongation and isolated torsade de pointes; avoid with known QT prolongation, uncorrected hypokalaemia/hypomagnesaemia, clinically significant bradycardia, acute myocardial ischaemia and class IA/III antiarrhythmics.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Serious hypersensitivity reactions, severe skin reactions, hepatotoxicity and haematological reactions; discontinue at first sign of rash, jaundice or hypersensitivity.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Clostridioides difficile-associated diarrhoea may occur.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Blood glucose disturbances (hypo- and hyperglycaemia), mainly in elderly diabetics on oral hypoglycaemics or insulin.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Photosensitivity/phototoxicity; avoid excessive sun or UV exposure.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Seizures and increased intracranial pressure; use with caution in known or suspected CNS disorders.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Multivalent cations (antacids, sucralfate, iron, zinc, multivitamins)Decreased moxifloxacin absorption; separate doses (4 h before or 8 h after).DailyMed (U.S. National Library of Medicine)
• WarfarinAnticoagulant effect may be enhanced; monitor prothrombin time/INR and bleeding.DailyMed (U.S. National Library of Medicine)
• Class IA and class III antiarrhythmicsProarrhythmic (QT) effect may be enhanced; avoid concomitant use.DailyMed (U.S. National Library of Medicine)
• Antidiabetic agentsDysglycaemia reported; monitor blood glucose carefully.DailyMed (U.S. National Library of Medicine)
• NSAIDsMay increase risk of CNS stimulation and convulsions.DailyMed (U.S. National Library of Medicine)

• No human data establishing a drug-associated risk; based on animal studies moxifloxacin may cause fetal harm; advise pregnant women of the potential risk.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Not known whether present in human milk; excreted at very low levels in rat milk; weigh benefits of breastfeeding against maternal need and potential infant effects.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Monitor ECG in patients with liver cirrhosis; monitor blood glucose in diabetics; monitor INR with warfarin.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Bactericidal; inhibits bacterial topoisomerase II (DNA gyrase) and topoisomerase IV required for DNA replication, transcription, repair and recombination (US label).