دواعي استعمال رازانتامين 24مجم 10 كبسول

Galantamine 24 mg extended-release capsules (acetylcholinesterase inhibitor) for Alzheimer's dementia; 10 capsules, Aug Pharma.

• Mild to moderate dementia of the Alzheimer's typeالفئة: AdultsDailyMed (U.S. National Library of Medicine)

• Most common (at least 5% and twice placebo): nausea, vomiting, diarrhoea, dizziness, headache and decreased appetite.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to galantamine hydrobromide or any excipient.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Serious skin reactions (Stevens-Johnson syndrome, acute generalized exanthematous pustulosis); discontinue at first appearance of rash.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Vagotonic effects: bradycardia and heart block, including in patients without known conduction abnormalities.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Increased gastric acid secretion; monitor for active or occult gastrointestinal bleeding, especially with ulcer history or NSAIDs.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• May cause bladder outflow obstruction; cholinomimetics may cause generalized convulsions; use with care in severe asthma or obstructive pulmonary disease.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Higher mortality was seen with galantamine in two trials in mild cognitive impairment (not an approved use).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Anticholinergic medicationsGalantamine may interfere with their activity.DailyMed (U.S. National Library of Medicine)
• Succinylcholine-type muscle relaxants and other cholinergic agonists/cholinesterase inhibitorsSynergistic effect expected.DailyMed (U.S. National Library of Medicine)
• Paroxetine (strong CYP2D6 inhibitor)Increased galantamine oral bioavailability by about 40%.DailyMed (U.S. National Library of Medicine)
• Ketoconazole (strong CYP3A4 inhibitor)Increased galantamine AUC by about 30%.DailyMed (U.S. National Library of Medicine)

• No adequate data in pregnant women; developmental toxicity in animal studies at clinically relevant doses; may cause fetal harm.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• No data on presence in human milk, effects on breastfed infant or milk production.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Reversible, competitive acetylcholinesterase inhibitor, thought to enhance cholinergic function (US label).