دواعي استعمال ريالكوكستار 90مجم 20 قرص

Etoricoxib 90 mg film-coated tablets, a selective COX-2 inhibitor NSAID; 20 tablets (2 strips), Tristar.

• Symptomatic relief of osteoarthritis, rheumatoid arthritis and ankylosing spondylitisالفئة: Adults and adolescents 16 years and olderelectronic medicines compendium (eMC)
• Pain and signs of inflammation associated with acute gouty arthritisالفئة: Adults and adolescents 16 years and olderelectronic medicines compendium (eMC)
• Short-term treatment of moderate pain after dental surgeryالفئة: Adults and adolescents 16 years and olderelectronic medicines compendium (eMC)

• Very common: abdominal pain. Common: alveolar osteitis, oedema/fluid retention, dizziness, headache, palpitations, hypertension, bronchospasm, GI disorders (dyspepsia, nausea, diarrhoea), raised ALT/AST, ecchymosis, asthenia/fatigue, flu-like illness.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)

• Hypersensitivity; active peptic ulcer or GI bleeding; bronchospasm, rhinitis, polyps, angioedema, urticaria or allergy after aspirin/NSAIDs; pregnancy and lactation; severe hepatic dysfunction; CrCl below 30 mL/min; under 16 years; inflammatory bowel disease; congestive heart failure (NYHA II-IV); uncontrolled hypertension (persistently above 140/90 mmHg); established ischaemic heart disease, peripheral arterial disease and/or cerebrovascular disease.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)

• Upper GI complications (perforation, ulcers, bleeding), higher with aspirin co-use, elderly and prior GI disease.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)
• Increased risk of thrombotic cardiovascular events with selective COX-2 inhibitors; use lowest dose for shortest duration; caution with cardiovascular risk factors.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)
• Fluid retention, oedema and hypertension; monitor blood pressure within two weeks of starting and periodically.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)
• Renal function deterioration in patients with pre-existing renal impairment, heart failure or cirrhosis; hepatic enzyme elevations.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)
• Serious skin reactions (including SJS/TEN), mostly in the first month; may mask fever; contains lactose.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)

• WarfarinINR increased by about 13% with etoricoxib 120 mg; monitor INR when starting or changing dose.electronic medicines compendium (eMC)
• Diuretics, ACE inhibitors, angiotensin II antagonistsReduced antihypertensive effect and risk of acute renal impairment; monitor renal function.electronic medicines compendium (eMC)
• Acetylsalicylic acidIncreased rate of GI ulceration; not a substitute for cardiovascular aspirin prophylaxis.electronic medicines compendium (eMC)
• Ciclosporin, tacrolimusNephrotoxic effect may be increased; monitor renal function.electronic medicines compendium (eMC)
• LithiumIncreased plasma lithium; monitor.electronic medicines compendium (eMC)
• MethotrexateMonitor for methotrexate toxicity at doses above 90 mg etoricoxib.electronic medicines compendium (eMC)
• Oral contraceptives (ethinylestradiol)Ethinylestradiol AUC increased by 37-60%; consider in contraceptive choice.electronic medicines compendium (eMC)
• RifampicinEtoricoxib AUC decreased by 65%.electronic medicines compendium (eMC)

• Contraindicated in pregnancy; if a woman becomes pregnant, treatment must be stopped.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)
• Contraindicated in breast-feeding women.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)

• Oral selective cyclo-oxygenase-2 (COX-2) inhibitor (UK SmPC).