دواعي استعمال ريكوفول 10مجم/مل 50 مل فيال

Propofol 10 mg/mL emulsion for intravenous injection/infusion, 50 mL, a short-acting general anaesthetic and sedative for hospital use.

• Induction of general anaesthesia.الفئة: Patients 3 years and olderDailyMed (U.S. National Library of Medicine)
• Maintenance of general anaesthesia.الفئة: Patients 2 months and olderDailyMed (U.S. National Library of Medicine)
• Initiation and maintenance of monitored anaesthesia care (MAC) sedation.الفئة: AdultsDailyMed (U.S. National Library of Medicine)
• Sedation of intubated, mechanically ventilated patients in intensive care units.الفئة: AdultsDailyMed (U.S. National Library of Medicine)

• Common (>1%): bradycardia, arrhythmia, hypotension, hypertension, decreased cardiac output, movement, injection-site burning/stinging/pain, apnoea, rash, pruritus, hyperlipaemia, respiratory acidosis during weaning.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to propofol or any component.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Allergy to eggs, egg products, soybeans or soy products.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Anaphylactic and anaphylactoid reactions have been reported.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Emulsion supports microbial growth: failure to follow aseptic handling has been associated with fever, infection, sepsis and death.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Propofol infusion syndrome (metabolic acidosis, rhabdomyolysis, hyperkalaemia, cardiac failure) reported, mainly with prolonged high-dose infusions (>5 mg/kg/h for >48 h).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Bradycardia, asystole, hypotension and apnoea may occur; seizures and hypertriglyceridaemia have been reported.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Repeated or lengthy use of general anaesthetics and sedation in children under 3 years or in the third trimester may affect brain development.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Contains EDTA: consider zinc supplementation during prolonged therapy (>5 days) or in patients predisposed to zinc deficiency.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Abuse and dependence have been reported, notably among health-care professionals.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Opioids, benzodiazepines and other CNS depressantsConcurrent premedication or sedatives increase anaesthetic/sedative effects and may cause more pronounced decreases in blood pressure and cardiac output; lower propofol doses may be required.DailyMed (U.S. National Library of Medicine)
• ValproateValproate increases blood levels of propofol; consider reducing the propofol dose.DailyMed (U.S. National Library of Medicine)
• Fentanyl (paediatric)Serious bradycardia has been reported in children given propofol with fentanyl.DailyMed (U.S. National Library of Medicine)

• Published studies in pregnant women have not identified a drug-associated risk of major birth defects; propofol crosses the placenta and may be associated with neonatal depression. Not recommended for obstetrics including caesarean section.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Propofol is present in human milk; consider the developmental and health benefits of breastfeeding with the mother's clinical need and potential adverse effects on the infant.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Continuously monitor vital signs and oxygenation; in ICU monitor triglycerides with prolonged use, and assess for signs of propofol infusion syndrome.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Sedative-hypnotic; positive modulation of GABA-A receptor-mediated inhibition (label: mechanism not fully characterized).