دواعي استعمال ريكوكسبرايت 120مجم 7 قرص

Etoricoxib 120 mg oral tablets (7), a selective COX-2 inhibitor NSAID for osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute gout and short-term dental post-operative pain.

• Symptomatic relief of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and pain and signs of inflammation associated with acute gouty arthritis.الفئة: Adults and adolescents 16 years and olderelectronic medicines compendium (eMC)
• Short-term treatment of moderate pain associated with dental surgery.الفئة: Adults and adolescents 16 years and olderelectronic medicines compendium (eMC)

• Very common: abdominal pain. Common: alveolar osteitis, oedema/fluid retention, dizziness, headache, palpitations, arrhythmia, hypertension, bronchospasm, GI disorders (constipation, flatulence, gastritis, heartburn, diarrhoea, dyspepsia, nausea), ALT/AST increased, ecchymosis, asthenia/fatigue, flu-like illness.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)

• Hypersensitivity to etoricoxib or excipients.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)
• Active peptic ulceration or active gastrointestinal bleeding.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)
• History of bronchospasm, acute rhinitis, nasal polyps, angioneurotic oedema, urticaria or allergic reactions after aspirin or NSAIDs (including COX-2 inhibitors).نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)
• Pregnancy and lactation.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)
• Severe hepatic dysfunction (albumin <25 g/L or Child-Pugh >=10).نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)
• Estimated creatinine clearance <30 mL/min.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)
• Children and adolescents under 16 years.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)
• Inflammatory bowel disease.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)
• Congestive heart failure (NYHA II-IV).نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)
• Hypertension with blood pressure persistently above 140/90 mmHg and not adequately controlled.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)
• Established ischaemic heart disease, peripheral arterial disease and/or cerebrovascular disease.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)

• Upper GI complications (perforations, ulcers, bleeding), some fatal, can occur; higher risk in the elderly, with concomitant aspirin/NSAIDs or prior GI disease.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)
• Selective COX-2 inhibitors may carry an increased risk of thrombotic events (especially MI and stroke); risk may rise with dose and duration.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)
• Renal prostaglandin inhibition may reduce renal perfusion; monitor renal function in at-risk patients.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)
• Fluid retention, oedema and hypertension may occur; monitor blood pressure within two weeks of starting and periodically thereafter.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)
• Elevations of ALT/AST have been reported; discontinue if persistent abnormal liver tests.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)
• Serious skin reactions (including Stevens-Johnson syndrome and toxic epidermal necrolysis) have been reported; discontinue at first appearance of rash.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)
• May mask fever and other signs of infection.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)
• Contains lactose: not for patients with rare hereditary galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)

• Warfarin (oral anticoagulants)Etoricoxib 120 mg daily increased prothrombin time INR by about 13%; monitor INR when starting or changing etoricoxib.electronic medicines compendium (eMC)
• Diuretics, ACE inhibitors, angiotensin II antagonistsNSAIDs may reduce the antihypertensive effect and, in compromised renal function, increase the risk of renal impairment.electronic medicines compendium (eMC)
• Acetylsalicylic acid (aspirin)Low-dose aspirin can be co-administered but increases GI ulceration risk; not a substitute for aspirin cardiovascular prophylaxis.electronic medicines compendium (eMC)
• Ciclosporin, tacrolimusNephrotoxic effect may be increased; monitor renal function.electronic medicines compendium (eMC)
• LithiumNSAIDs decrease lithium renal excretion and increase plasma levels; monitor lithium levels.electronic medicines compendium (eMC)
• MethotrexateMonitor for methotrexate toxicity when etoricoxib >90 mg daily is combined with methotrexate.electronic medicines compendium (eMC)
• Oral contraceptives (ethinylestradiol)Etoricoxib 60-120 mg increased ethinylestradiol AUC by about 37-60%; consider in choice of contraceptive.electronic medicines compendium (eMC)
• RifampicinRifampicin decreased etoricoxib AUC by about 65%; may cause recurrence of symptoms.electronic medicines compendium (eMC)
• DigoxinEtoricoxib increased digoxin Cmax by about 33%; monitor patients at high risk of digoxin toxicity.electronic medicines compendium (eMC)

• Contraindicated in pregnancy; in the third trimester NSAIDs may cause premature closure of the ductus arteriosus and uterine inertia. Discontinue if pregnancy occurs.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)
• Unknown whether excreted in human milk (excreted in rat milk); women using etoricoxib must not breastfeed.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)

• Monitor blood pressure (within 2 weeks of initiation and periodically), renal and hepatic function in at-risk patients.نشرة دولية لنفس التركيبة · electronic medicines compendium (eMC)

• Selective inhibition of COX-2, reducing prostaglandin formation involved in pain and inflammation.