دواعي استعمال ريمتوزار دي 25/100مجم 10 اقراص

Losartan potassium 100 mg + hydrochlorothiazide 25 mg film-coated tablets, pack of 10.

• HypertensionDailyMed (U.S. National Library of Medicine)
• Reduction of stroke risk in hypertensive patients with left ventricular hypertrophyDailyMed (U.S. National Library of Medicine)

• Events >2% and more than placebo: back pain, dizziness and upper respiratory infection.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to any component; co-administration with aliskiren in patients with diabetes.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Anuria.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Boxed warning - fetal toxicity: discontinue losartan/hydrochlorothiazide as soon as pregnancy is detected; drugs acting on the renin-angiotensin system can injure or kill the developing fetus.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Symptomatic hypotension may occur in volume- or salt-depleted patients (e.g. high-dose diuretics); correct depletion before starting.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Renal function deterioration, including acute renal failure, in patients dependent on the renin-angiotensin system (renal artery stenosis, CKD, severe heart failure, volume depletion).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Hydrochlorothiazide can cause hypokalaemia, hyponatraemia, and hypomagnesaemia; acute myopia and secondary angle-closure glaucoma; may activate systemic lupus erythematosus; hypersensitivity reactions.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Potassium-raising drugs (potassium-sparing diuretics, potassium supplements, salt substitutes)Risk of hyperkalaemia; monitor serum potassium.DailyMed (U.S. National Library of Medicine)
• LithiumIncreased serum lithium and toxicity reported; monitor lithium levels.DailyMed (U.S. National Library of Medicine)
• NSAIDs including COX-2 inhibitorsIn elderly, volume-depleted or renally impaired patients may worsen renal function, possibly acute renal failure (usually reversible); monitor renal function.DailyMed (U.S. National Library of Medicine)
• ACE inhibitors, other ARBs, aliskiren (dual RAS blockade)Increased hypotension, syncope, hyperkalaemia and renal function changes; avoid combined use.DailyMed (U.S. National Library of Medicine)

• Use in the second and third trimesters reduces fetal renal function and increases fetal and neonatal morbidity and death (oligohydramnios, lung hypoplasia, skeletal deformations, neonatal hypotension, anuria, renal failure).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Unknown whether losartan is excreted in human milk; significant levels found in rat milk; decide whether to discontinue nursing or the drug.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Monitor blood pressure, serum potassium and renal function.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)